The aim of the course is to give information on general principles and molecular aspects on how drugs act, drugs discovery and development, targets for drug action and quantitative aspect of drug–receptors interactions, absorption, distribution and excretion of drugs in the body, pharmacokinetics and therapeutic drug monitoring.
Prerequisiti
Prerequisites for this course are Anatomy, Physiology and Biochemistry.
Metodi didattici
The course includes formal and interactive lectures. The professor is available to provide clarifications about topics included in the course. Professor contacts: andrea.ferrigno@unipv.it +39 0382986451
Verifica Apprendimento
Written examination consisting of multiple choice questions, primarily based upon the didactic material covered in the course.
Testi
Goodman and Gilman's The Pharmacological Basis of Therapeutics (Laurence Brunton, Bruce Chabner, Bjorn Knollman, authors), Twelfth Edition, New York McGraw-Hill, 2011 Harvey RA, Clark MA, Finkel R, Rey JA, Whalen, K. Lippincott’s illustrated reviews: Pharmacology, 5th Edition, Lippincott, Williams & Wilkins), 2011 Katzung, BG, Master SB, Trevor A J. Basic and Clinical Pharmacology; New York: McGraw-Hill Medical, 2012 Waller DG, Renwick AG, Hillier K. Medical Pharmacology and Therapeutics, 3rd edition. W. B. Saunders, London, 2009
Contenuti
The program is composed of the following topics: - Routes of drug administration - Crossing of lipid barriers: passive diffusion, transporters, endocytosis - Fick's law - Definition of absorption, distribution, metabolism, and elimination, and basic parameters - Receptor theories - Affinity and fractional occupancy - Efficacy - Competitive and non-competitive antagonism, orthosteric and allosteric antagonists - Classification of receptors - Examples of receptors Only the content presented by the teacher in class will be required for the exam. For further details on the program, it is recommended to consult the slides available on the KIRO platform.
Lingua Insegnamento
INGLESE
Altre informazioni
To plan a meeting, write to andrea.ferrigno@unipv.it