-to develop a knowledge base of stereoselective organic reactions. -to master an understanding of structure-reactivity principles of asymmetric catalysis. -to gain the ability to devise synthetic strategies for complex molecule construction requiring chemo-, regio-, and stereoselective transformations. -to develop fundamental critical thinking skills, including pattern recognition and analogous reasoning.
Prerequisiti
Basic knowledge of organic synthesis and stereochemistry
Metodi didattici
Lecture room-based presentations
Verifica Apprendimento
Oral exam
Testi
P. J. Walsh and M. C. Kozlowski, Fundamentals of Asymmetric Catalysis, University Science Books, 2008
E. M. Carreira, L. Kvaerno, Classics in Stereoselective Synthesis, Wiley-VCH, 2008.
Contenuti
Lewis Acid/Base Catalysis Basic principles, historical survey Lewis acid catalysis Lewis base catalysis
Brønsted Acid/Base and Hydrogen Bonding Catalysis Brønsted acid catalysis Brønsted base catalysis Electrostatic and Anion binding catalysis
Principles of Asymmetric of Catalysis Diastereomeric interactions and nonlinear effects Asymmetric amplification and reservoir effects Autocatalysis and absolute asymmetric synthesis Asymmetric autoinduction
