ID:
509943
Durata (ore):
52
CFU:
6
SSD:
PATOLOGIA GENERALE
Anno:
2024
Dati Generali
Periodo di attività
Secondo Semestre (03/03/2025 - 13/06/2025)
Syllabus
Obiettivi Formativi
The aim of the module is to introduce students to cancer disease focusing on causes, mechanisms, and molecular targets.
The module will allow the student to obtain a comprehensive knowledge about: tumor classification (grading, staging, molecular analysis); principles of cancer epidemiology; biological and molecular mechanisms of physical, chemical and biological carcinogenesis; interactions of tumor cells with the microenvironment and the immune system; tumor progression, evolution and metastatic spread.
At the end of the course students will be able to analyze the vast complexity of cancer disease field in a critical light with the awareness of the hallmarks of cancer.
The module will allow the student to obtain a comprehensive knowledge about: tumor classification (grading, staging, molecular analysis); principles of cancer epidemiology; biological and molecular mechanisms of physical, chemical and biological carcinogenesis; interactions of tumor cells with the microenvironment and the immune system; tumor progression, evolution and metastatic spread.
At the end of the course students will be able to analyze the vast complexity of cancer disease field in a critical light with the awareness of the hallmarks of cancer.
Prerequisiti
Understanding the topics covered in the Cancer module requires a knowledge of the animal eukaryotic cell biology, the main biochemical processes and macromolecules involved, the main human anatomical districts and physiological functions.
Metodi didattici
Lectures, self-assessment test, multimedia tools, discussion of recent publications related to lecture topics.
Verifica Apprendimento
The learning test will take place in written form and will be included in the Degenerative Diseases and Cancer exam
Testi
Lauren Pecorino. Molecular Biology of Cancer. Mechanisms, Targets, and Therapeutics. 5th edition-2021. Oxford University Press.
Francesco Pezzella, Mahvash Tavassoli, David J. Kerr. Oxford Textbook of Cancer Biology. 1st edition-2019-Oxford University Press.
Vincent T. DeVita Jr., Theodore S. Lawrence, Sreven A. Rosenberg. DeVita, Hellman, and Rosenberg’s Cancer Principles & Practice of Oncology, Primer of the Molecular Biology of Cancer. 3rd edition-2021-Wolters Kluwer.
The slides of the lectures, the suggested research articles and the e-book “ Lollini: Cellular & Molecular Oncology” will be available in Kiro site.
Francesco Pezzella, Mahvash Tavassoli, David J. Kerr. Oxford Textbook of Cancer Biology. 1st edition-2019-Oxford University Press.
Vincent T. DeVita Jr., Theodore S. Lawrence, Sreven A. Rosenberg. DeVita, Hellman, and Rosenberg’s Cancer Principles & Practice of Oncology, Primer of the Molecular Biology of Cancer. 3rd edition-2021-Wolters Kluwer.
The slides of the lectures, the suggested research articles and the e-book “ Lollini: Cellular & Molecular Oncology” will be available in Kiro site.
Contenuti
Cancer BIOLOGY MODULE (1 CFU):
Terminology and classification.
Causes of cancer (chemical, physical and infectious). Mutagenicity and carcinogenicity, The transformed cell phenotype. Cancer and environmental pollution. Cancer prevention and cancer therapy.
Driver and passenger mutations. Proto oncogene families, examples (EGFR, HER2, myc, ras, abl, braf) and mechanisms of de-regulation in human cancer. Tumour suppressor genes. Discovery, examples (TP53, pRb, APC, BRCA and BRCAness) and mechanisms of inactivation. Target therapy: new challenges.
Cancer progression. Metastasis. The movement of animal cells: major types and their regulation. Cell movement in cancer. Loss of contact inhibition. Epithelial-to-mesenchymal transition. The major steps of the metastasis process. The seed and soil hypothesis. ‘Homing’ cancer cells in metastasis. B Vogelstein’s linear model of cancer progression. The discovery of cancer stem cells. Tumor evolution. Rest phase. Pre-clinical models to study cancer progression (in vitro, in vivo and in silico).
Tumour angiogenesis and metabolism. Tumour vasculature. Signals, pathways, targets and therapy. Metabolomic. Pathways and targets.
Cancer Immunity. The concept of immune surveillance. Immunoediting.
Terminology and classification.
Causes of cancer (chemical, physical and infectious). Mutagenicity and carcinogenicity, The transformed cell phenotype. Cancer and environmental pollution. Cancer prevention and cancer therapy.
Driver and passenger mutations. Proto oncogene families, examples (EGFR, HER2, myc, ras, abl, braf) and mechanisms of de-regulation in human cancer. Tumour suppressor genes. Discovery, examples (TP53, pRb, APC, BRCA and BRCAness) and mechanisms of inactivation. Target therapy: new challenges.
Cancer progression. Metastasis. The movement of animal cells: major types and their regulation. Cell movement in cancer. Loss of contact inhibition. Epithelial-to-mesenchymal transition. The major steps of the metastasis process. The seed and soil hypothesis. ‘Homing’ cancer cells in metastasis. B Vogelstein’s linear model of cancer progression. The discovery of cancer stem cells. Tumor evolution. Rest phase. Pre-clinical models to study cancer progression (in vitro, in vivo and in silico).
Tumour angiogenesis and metabolism. Tumour vasculature. Signals, pathways, targets and therapy. Metabolomic. Pathways and targets.
Cancer Immunity. The concept of immune surveillance. Immunoediting.
Lingua Insegnamento
INGLESE
Altre informazioni
Students can contact the teacher by e-mail to ask for clarification on the content of the lessons and on the study material or to request an appointment.
The teacher will provide the learning test correction and will be always available for any clarifications.
arianna.palladini@unipv.it
The teacher will provide the learning test correction and will be always available for any clarifications.
arianna.palladini@unipv.it
Corsi
Corsi
MEDICAL AND PHARMACEUTICAL BIOTECHNOLOGIES
Laurea Magistrale
2 anni
No Results Found
Persone
Persone (3)
Personale tecnico amministrativo
No Results Found