ID:
509950
Durata (ore):
24
CFU:
3
SSD:
MALATTIE INFETTIVE
Anno:
2024
Dati Generali
Periodo di attività
Secondo Semestre (03/03/2025 - 13/06/2025)
Syllabus
Obiettivi Formativi
The general objective of this module is to introduce the molecular processes underlying infections in humans and how to tackle the current and emerging challenges in this field at a molecular level.
Specific objectives are:
Understanding of the molecular mechanisms bacteria and viruses use to infect hosts, evade immune defenses, and establish infections; Gaining insight on the structural biology of key molecular components of bacteria and viruses involved in infection; Gaining insight on the basic principles underlying the structure and dynamics of intrinsically disordered proteins (IDPs) and exploring the their roles in bacterial and viral pathogenesis; Understanding the mechanisms of action of common antibacterial and antiviral agents; Learning the principles of structure-based design of antimicrobial agents; Understanding the molecular bases of antibiotic and antiviral resistance, and gaining insight on the implications for public health; Understanding the molecular biology and mechanisms underlying prion diseases, and exploring current and novel therapeutic strategies for prion diseases.
Specific objectives are:
Understanding of the molecular mechanisms bacteria and viruses use to infect hosts, evade immune defenses, and establish infections; Gaining insight on the structural biology of key molecular components of bacteria and viruses involved in infection; Gaining insight on the basic principles underlying the structure and dynamics of intrinsically disordered proteins (IDPs) and exploring the their roles in bacterial and viral pathogenesis; Understanding the mechanisms of action of common antibacterial and antiviral agents; Learning the principles of structure-based design of antimicrobial agents; Understanding the molecular bases of antibiotic and antiviral resistance, and gaining insight on the implications for public health; Understanding the molecular biology and mechanisms underlying prion diseases, and exploring current and novel therapeutic strategies for prion diseases.
Prerequisiti
Basic knowledge of the biochemistry of proteins and other biological macromolecules, molecular cell biology and immunology is required.
Metodi didattici
Lectures, based on traditional chalk and board method and power point presentations; Voluntary individual and group activities like flash
presentations and seminars.
presentations and seminars.
Verifica Apprendimento
The learning test will take place in written form, with open- and multi-choice questions. Individual and group activities will be taken into consideration as extra-points for evaluation.
Testi
Recent book chapters and review articles suitable for each section will be introduced in due course.
Contenuti
Molecular Mechanisms of Bacterial Infections:
Introduction to bacterial infections, Bacterial adherence and colonization, invasion and intracellular survival, Evasion of host immune system, Virulence factors and their molecular mechanisms;
Molecular Mechanisms of Viral Infections:
Introduction to viral infections, Viral attachment and entry into host cells, Viral genome replication and transcription, Viral protein synthesis, assembly, and evasion of host immune system, Molecular mechanisms of viral pathogenesis and disease; Structural Biology of Bacterial Infections: Introduction to key structural techniques, Membrane receptors and toxins in bacterial pathogenesis, Bacterial secretion systems, Enzymes and virulence factors, Host-pathogen interaction at the structural level; Structural Biology of Viral Infections: Virus receptors and host cell entry, Viral capsid structure and genome release, Viral enzymes and replication machinery; Intrinsically Disordered Proteins, Aggregation and Phase Separation in Infection Biology; Mechanisms of Action of Anti-bacterial Agents; Mechanisms of Action of Anti-viral Agents; Structure-based Design of Antibacterial and Antiviral Drugs; Mechanisms of Antibiotic and Antiviral Resistance: Molecular mechanisms of antimicrobial resistance, Global impact of resistance, Novel approaches to combat resistance; Molecular Pathogenesis and Therapeutic Strategies in Prion Diseases.
Introduction to bacterial infections, Bacterial adherence and colonization, invasion and intracellular survival, Evasion of host immune system, Virulence factors and their molecular mechanisms;
Molecular Mechanisms of Viral Infections:
Introduction to viral infections, Viral attachment and entry into host cells, Viral genome replication and transcription, Viral protein synthesis, assembly, and evasion of host immune system, Molecular mechanisms of viral pathogenesis and disease; Structural Biology of Bacterial Infections: Introduction to key structural techniques, Membrane receptors and toxins in bacterial pathogenesis, Bacterial secretion systems, Enzymes and virulence factors, Host-pathogen interaction at the structural level; Structural Biology of Viral Infections: Virus receptors and host cell entry, Viral capsid structure and genome release, Viral enzymes and replication machinery; Intrinsically Disordered Proteins, Aggregation and Phase Separation in Infection Biology; Mechanisms of Action of Anti-bacterial Agents; Mechanisms of Action of Anti-viral Agents; Structure-based Design of Antibacterial and Antiviral Drugs; Mechanisms of Antibiotic and Antiviral Resistance: Molecular mechanisms of antimicrobial resistance, Global impact of resistance, Novel approaches to combat resistance; Molecular Pathogenesis and Therapeutic Strategies in Prion Diseases.
Lingua Insegnamento
INGLESE
Altre informazioni
Students are welcome to communicate with the teacher through email if they have any question about the content of the lessons and, if needed, request an appointment for an in-person or online meeting.
Corsi
Corsi
MEDICAL AND PHARMACEUTICAL BIOTECHNOLOGIES
Laurea Magistrale
2 anni
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