511573 - GENOMICS AND EPIGENOMICS IN MEDICAL AND PHARMACEUTICAL FIELDS

Students will be able to: 1. Understand the organization of the human genome and become familiar with modern, genome-wide methods used in genomics research. 2. Study the structure and function of centromeres and telomeres, the two main structures required for the correct function and integrity of the chromosomes. 3. Gain insight into the impact of the genome sequencing revolution and its major applications across medical disciplines, with particular emphasis on oncology. 4. Examine how genetic variation affects drug response, using examples to illustrate the principles of pharmacogenomics. 5. Learn the concept of the epigenome, including chromatin architecture and its chemical modifications, and how these contribute to the regulation of genome function. 6. Explore the role of epigenetic modifications in human development and disease, supported by some case studies. 7. Understand the principles behind epigenetic therapies, with specific examples demonstrating their mechanisms and potential clinical applications. 8. Read scientific articles understanding their organization and relevance. This activity is designed to enhance their comprehension of current research topics and to support the development of skills necessary for their exam presentations.