[Female breast cancer and occupational sectors: a preliminary study in the provinces of Lombardy, Italy].
Articolo
Data di Pubblicazione:
2014
Abstract:
Background. The role of occupational exposures in
breast cancer development is still uncertain. A recent paper
showed increased risks in some occupational sectors in
Lombardy, Italy. We deepened this analysis at the level of singleprovinces of the same Italian region.
Methods. Based on administrative data, a case-control study was
carried out recruiting all incident cases of female breast cancer in the period 2002-2009, aged between 35 and 69 years, residing in Lombardy, Italy. Controls were randomly sampled from all women residing in Lombardy as of December 31, 2005.
Occupational histories, including blue collar status, were
available from 1974 through record linkage with a social security
pension database, and were obtained for 11188 cases and 25329 controls. Adjusted odds ratios (ORs) and corresponding 90% confidence intervals (CIs) were calculated using multiple
unconditional logistic regression models. Analyses were
performed also by single provinces of Lombardy, Italy.
Multiple comparisons were accounted for according to the
Benjamini-Hochberg method.
Results. The ORs for female breast cancer were modestly
but significantly increased for employment in electrical
manufacturing (OR 1.12, 90% CI 1.04-1.21), textile (OR 1.08,
90% CI 1.02-1.15), paper (OR 1.25, 90% CI 1.06-1.46) and rubber
(OR 1.26, 90% CI 1.03-1.54) industries. Analysis by province
showed significantly increased ORs for electrical manufacturing
in the Milano province. After adjustment for multiple
comparisons no estimates remained statistically significant,
except OR for electrical manufacturing in the Milano province.
Conclusions. Although with several limitations, our results point
to a possible role of exposures in electrical manufacturing,
textile, paper and rubber industries in the process leading to
breast cancer. An in-dept study for the electrical manufacturing industry has been already planned in Milano province.
Tipologia CRIS:
1.1 Articolo in rivista
Keywords:
female breast cancer; occupational exposure; electrical manufacturing; Case-control Study; OCCAM project
Elenco autori:
Oddone, Enrico; Edefonti, V; Scaburri, A; Vai, T; Modonesi, C; Crosignani, Paolo; Imbriani, Marcello
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