Multicenter comparative multimodality surveillance of women at genetic-familial high risk for breast cancer (HIBCRIT Study): Interim results
Articolo
Data di Pubblicazione:
2007
Abstract:
PURPOSE:
To prospectively compare clinical breast examination (CBE), mammography, ultrasonography (US), and contrast material-enhanced magnetic resonance (MR) imaging for screening women at genetic-familial high risk for breast cancer and report interim results, with pathologic findings as standard.
MATERIALS AND METHODS:
Institutional review board of each center approved the research; informed written consent was obtained. CBE, mammography, US, and MR imaging were performed for yearly screening of BRCA1 or BRCA2 mutation carriers, first-degree relatives of BRCA1 or BRCA2 mutation carriers, or women enrolled because of a strong family history of breast or ovarian cancer (three or more events in first- or second-degree relatives in either maternal or paternal line; these included breast cancer in women younger than 60 years, ovarian cancer at any age, and male breast cancer at any age).
RESULTS:
Two hundred seventy-eight women (mean age, 46 years +/- 12 [standard deviation]) were enrolled. Breast cancer was found in 11 of 278 women at first round and seven of 99 at second round (14 invasive, four intraductal; eight were
CONCLUSION:
Addition of MR imaging to the screening regimen for high-risk women may enable detection of otherwise unsuspected breast cancers.
To prospectively compare clinical breast examination (CBE), mammography, ultrasonography (US), and contrast material-enhanced magnetic resonance (MR) imaging for screening women at genetic-familial high risk for breast cancer and report interim results, with pathologic findings as standard.
MATERIALS AND METHODS:
Institutional review board of each center approved the research; informed written consent was obtained. CBE, mammography, US, and MR imaging were performed for yearly screening of BRCA1 or BRCA2 mutation carriers, first-degree relatives of BRCA1 or BRCA2 mutation carriers, or women enrolled because of a strong family history of breast or ovarian cancer (three or more events in first- or second-degree relatives in either maternal or paternal line; these included breast cancer in women younger than 60 years, ovarian cancer at any age, and male breast cancer at any age).
RESULTS:
Two hundred seventy-eight women (mean age, 46 years +/- 12 [standard deviation]) were enrolled. Breast cancer was found in 11 of 278 women at first round and seven of 99 at second round (14 invasive, four intraductal; eight were
CONCLUSION:
Addition of MR imaging to the screening regimen for high-risk women may enable detection of otherwise unsuspected breast cancers.
Tipologia CRIS:
1.1 Articolo in rivista
Keywords:
BRCA2 Protein; Breast Neoplasms; Female; Genetic Testing; Humans; Italy; Magnetic Resonance Imaging; Middle Aged; Pilot Projects; Population Surveillance; Prevalence; Reproducibility of Results; Risk Assessment; Risk Factors; Sensitivity and Specificity; Ubiquitin-Protein Ligases; Radiology, Nuclear Medicine and Imaging
Elenco autori:
Sardanelli, Francesco; Podo, Franca; D'Agnolo, Giuliano; Verdecchia, Arduino; Santaquilani, Mariano; Musumeci, Renato; Trecate, Giovanna; Manoukian, Siranoush; Morassut, Sandro; de Giacomi, Clelia; Federico, Massimo; Cortesi, Laura; Corcione, Stefano; Cirillo, Stefano; Marra, Vincenzo; Cilotti, Anna; Di Maggio, Cosimo; Fausto, Alfonso; Preda, Lorenzo; Zuiani, Chiara; Contegiacomo, Alma; Orlacchio, Antonio; Calabrese, Massimo; Bonomo, Lorenzo; Di Cesare, Ernesto; Tonutti, Maura; Panizza, Pietro; Del Maschio, Alessandro; Bergonzi, Silvana; Costa, Claudia; Ferranti, Claudio; Marchesini, Monica; Scaperotta, Gianfranco; Suman, Laura; Vergnaghi, Daniele; Dolcetti, Riccardo; Viel, Alessandra; Venturini, Silvia; Romagnoli, Renato; Battista, Rachele; Canossi, Barbara; de Santis, Mario; Marchi, Isabella; Medici, Veronica; Turchetti, Daniela; Querzoli, Patrizia; Cellini, Lisa; Martincich, Laura; Regge, Daniele; Bartolozzi, Carlo; Bevilacqua, Generoso; Brunetti, Isa; Caligo, Maria Adelaide; Giaconi, Claudia; Iacconi, Chiara; Mazzotta, Dionisa; Moretti, Monica; Roncella, Manuela; Artioli, Grazia; D'Andrea, Emma; Nardelli, Gianni; Nicoletto, Maria Ornella; Pescarini, Luigi; Zavagno, Giorgio; Babaei, Bijan; Gerra, Francesco; Magaldi, Adamo; Iozzelli, Andrea; Lupo, Eleonora N.; Russo, Michela; Barile, Monica; Bazzi, Luca; Cassano, Enrico; Decensi, Andrea; Bellomi, Massimo; Bonanni, Bernardo; Feroce, Irene; Villa, Gaetano; Bazzocchi, Massimo; Bestagno, Alexia; Francescutti, Giuliana; Pensabene, Matilde; Capuano, Ida; Brizzi, Davide; Battista, Pasquale; Cama, Alessandro; Carriero, Alessandro; Mariani Costantini, Renato; Palka, Giandomenico; Ciccozzi, Antonietta; Colista, Franco; Fiumara, Caterina; Lelli, Silvia; Mancini, Maria; Masciocchi, Carlo; Ricevuto, Enrico; Amoroso, Antonio; Dellach, Carla; Mustacchi, Giorgio; Pozzi Mucelli, Roberto; De Gaspari, Angela; Fedele, Isabella
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