Dose intensification of chemotherapy in advanced breast cancer: a feasibility phase II study
Articolo
Data di Pubblicazione:
1994
Abstract:
Dose intensification of chemotherapy is associated with increased response rates in advanced breast cancer. Achievement of dose incrementation is usually limited by drug-dependent bone marrow toxicity. The recent availability of recombinant human colony-stimulating factors (CSFs) have made it possible to evaluate their potential in ameliorating chemotherapy-induced myelosuppression. The aim of this study was to evaluate tolerability and effectiveness of an intensified mitoxantrone, methotrexate and mitomycin-C (3M) regimen, given with G-CSF support in patients with advanced breast cancer (ABC).
Tipologia CRIS:
1.1 Articolo in rivista
Keywords:
Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Diseases; Breast Neoplasms; Drug Administration Schedule; Feasibility Studies; Female; Filgrastim; Granulocyte Colony-Stimulating Factor; Humans; Methotrexate; Middle Aged; Mitomycins; Mitoxantrone; Recombinant Proteins; Treatment Outcome
Elenco autori:
Pedrazzoli, P; Zamagni, C; Martoni, A; Capotorto, A M; Da Prada, G A; Pavesi, L; Preti, P; Lelli, G; Pannuti, F; Robustelli della Cuna, G
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