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Anaemia and abdominal pain due to occupational lead poisoning

Articolo
Data di Pubblicazione:
2007
Abstract:
We describe a 47-year-old patient with chronic anaemia with basophilic stippling of erythrocytes, recurrent abdominal colics, discoloration of gums, sensitive polyneuropathy to the four limbs, hyperuricaemia, hepatosteatosis with raised transaminases, and a long ignored history of lead exposure in a battery recycling plant. The diagnosis of poisoning was confirmed by high lead levels in the blood and urine, decreased erythrocyte delta-aminolevulinic acid dehydratase (ALA-D), raised erythrocyte zinc protoporphyrin (ZP), and elevated urinary excretion of porphyrins. Chelation with EDTA resulted in increased urinary lead excretion, gradual improvement of the clinical picture, and progressive normalization of lead biomarkers. The case highlights the importance of occupational anamnesis for the diagnosis of lead poisoning, an uncommon condition which may mimic a variety of internal and surgical diseases.
Tipologia CRIS:
1.1 Articolo in rivista
Keywords:
Plumbism; Occupational History; Chelation Therapy
Elenco autori:
Candura, Stefano; Fonte, Rodolfo; Agosti, Antonio; Scafa, Fabrizio
Autori di Ateneo:
CANDURA STEFANO
Link alla scheda completa:
https://iris.unipv.it/handle/11571/34332
Pubblicato in:
HAEMATOLOGICA
Journal
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URL

http://www.haematologica.org/content/92/2/e13.long
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