Duration of untreated prodromal symptoms and 12-month functional outcome of individuals at risk of psychosis

Individuals seeking help from prodromal services may have been experiencing attenuated psychotic features and psychosocial impairments for a long period prior to referral. The effect of an extended duration of these untreated 'at risk' symptoms on patients' long-term functional outcome was assessed in a 12-month longitudinal observational study (n=49). A longer duration of untreated 'at risk' symptoms was correlated with a reduced improvement in Global Assessment of Functioning scores after 12 months (β=-0.375, P=0.008). This effect was independent of age and gender and may have implications for the improvement of treatment strategies in pre-psychotic phases.