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Novel Medicinal Mushroom Blend as a Promising Supplement in Integrative Oncology: A Multi-Tiered Study using 4T1 Triple-Negative Mouse Breast Cancer Model

Articolo
Data di Pubblicazione:
2020
Abstract:
Abstract: Although medicinal mushroomextracts have been proposed as promising anti-cancer agents, their precise impacts on metastatic breast cancer are still to be clarified. For this purpose, the present study exploited the eect of a novel medicinal mushroom blend, namely Micotherapy U-care, in a 4T1 triple-negative mouse breast cancer model. Mice were orally administered with Micotherapy U-care, consisting of a mixture of Agaricus blazei, Ophiocordyceps sinensis, Ganoderma lucidum, Grifola frondosa, and Lentinula edodes. The syngeneic tumor-bearing mice were generated by injecting 4T1 cells in both supplemented and non-supplemented mice. After sacrifice 35 days later, specific endpoints and pathological outcomes of the murine pulmonary tissue were evaluated. (i) Histopathological and ultrastructural analysis and (ii) immunohistochemical assessment of TGF-ß1, IL-6 and NOS2, COX2, SOD1 as markers of inflammation and oxidative stress were performed. The QoL was comparatively evaluated. Micotherapy U-care supplementation, starting before 4T1 injection and lasting until the end of the experiment, dramatically reduced the pulmonary metastases density, also triggering a decrease of fibrotic response, and reducing IL-6, NOS, and COX2 expression. SOD1 and TGF-ß1 results were also discussed. These findings support the valuable potential of Micotherapy U-care as adjuvant therapy in the critical management of triple-negative breast cancer.
Tipologia CRIS:
1.1 Articolo in rivista
Keywords:
mycotherapy; breast cancer; lung metastasis; in vivo; complementary medicine; Agaricus blazei; Ophiocordyceps sinensis; Ganoderma lucidum; Grifola frondosa; Lentinula edodes
Elenco autori:
Roda, Elisa; De Luca, Fabrizio; Di Iorio, Carmine; Ratto, Daniela; Siciliani, Stella; Ferrari, Beatrice; Cobelli, Filippo; Borsci, Giuseppina; Priori, Erica Cecilia; Chinosi, Silvia; Ronchi, Andrea; Franco, Renato; Di Francia, Raffaele; Berretta, Massimiliano; Locatelli, Carlo Alessandro; Gregori, Andrej; Savino, Elena; Bottone, Maria Grazia; Rossi, Paola
Autori di Ateneo:
BOTTONE MARIA GRAZIA
DE LUCA FABRIZIO
LOCATELLI CARLO ALESSANDRO
PRIORI ERICA CECILIA
RATTO DANIELA
ROSSI PAOLA
SAVINO ELENA
Link alla scheda completa:
https://iris.unipv.it/handle/11571/1340787
Link al Full Text:
https://iris.unipv.it//retrieve/handle/11571/1340787/356913/76-RODA2020_compressed.pdf
Pubblicato in:
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Journal
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URL

https://www.mdpi.com/1422-0067/21/10/3479
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