Data di Pubblicazione:
2020
Abstract:
The molecular chaperone TRAP1 regulates energy metabolism, and its activity is relevant in cancer and degenerative diseases. Here, Sanchez-Martin et al. identify highly selective allosteric inhibitors of TRAP1. These compounds revert biochemical and pro-neoplastic effects of TRAP1 and could both enlighten its mode of action and disclose novel therapeutic strategies.
Tipologia CRIS:
1.1 Articolo in rivista
Keywords:
allosteric ligands; anticancer compound; cancer cells; chaperone inhibitors; HSP90; mitochondria; mitochondrial biology; molecular dynamics; neurofibroma; TRAP1; zebrafish
Elenco autori:
Sanchez-Martin, C.; Moroni, E.; Ferraro, M.; Laquatra, C.; Cannino, G.; Masgras, I.; Negro, A.; Quadrelli, P.; Rasola, A.; Colombo, G.
Link alla scheda completa:
Pubblicato in: