Data di Pubblicazione:
2004
Abstract:
The Mycobacterium tuberculosis Rv2686c-Rv2687c-Rv2688c operon, encoding an ABC transporter, conferred
resistance to ciprofloxacin and, to a lesser extent, norfloxacin, moxifloxacin, and sparfloxacin to Mycobacterium
smegmatis. The resistance level decreased in the presence of the efflux pump inhibitors reserpine, carbonyl
cyanide m-chlorophenylhydrazone, and verapamil. Energy-dependent efflux of ciprofloxacin from M. smegmatis
cells containing the Rv2686c-Rv2687c-Rv2688c operon was observed.
resistance to ciprofloxacin and, to a lesser extent, norfloxacin, moxifloxacin, and sparfloxacin to Mycobacterium
smegmatis. The resistance level decreased in the presence of the efflux pump inhibitors reserpine, carbonyl
cyanide m-chlorophenylhydrazone, and verapamil. Energy-dependent efflux of ciprofloxacin from M. smegmatis
cells containing the Rv2686c-Rv2687c-Rv2688c operon was observed.
Tipologia CRIS:
1.1 Articolo in rivista
Keywords:
Mycobacterium tuberculosis; drug resistance; efflux pump
Elenco autori:
Pasca, MARIA ROSALIA; Guglierame, Paola; Arcesi, Fabio; Bellinzoni, Marco; DE ROSSI, Edda; Riccardi, Giovanna
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