Data di Pubblicazione:
2020
Abstract:
We study a stochastic phase-field model for tumor growth dynamics coupling a stochastic Cahn-Hilliard equation for the tumor phase parameter with a stochastic reaction-diffusion equation governing the nutrient proportion. We prove strong well-posedness of the system in a general framework through monotonicity and stochastic compactness arguments. We introduce then suitable controls representing the concentration of cytotoxic drugs administered in medical treatment and we analyze a related optimal control problem. We derive existence of an optimal strategy and deduce first-order necessary optimality conditions by studying the corresponding linearized system and the backward adjoint system.
Tipologia CRIS:
1.1 Articolo in rivista
Keywords:
Stochastic systems of partial differential equations / Cahn-Hilliard equation / optimal control, first-order necessary conditions / tumor growth
Elenco autori:
Orrieri, Carlo; Rocca, Elisabetta; Scarpa, Luca
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