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Optimal control of stochastic phase-field models related to tumor growth

Articolo
Data di Pubblicazione:
2020
Abstract:
We study a stochastic phase-field model for tumor growth dynamics coupling a stochastic Cahn-Hilliard equation for the tumor phase parameter with a stochastic reaction-diffusion equation governing the nutrient proportion. We prove strong well-posedness of the system in a general framework through monotonicity and stochastic compactness arguments. We introduce then suitable controls representing the concentration of cytotoxic drugs administered in medical treatment and we analyze a related optimal control problem. We derive existence of an optimal strategy and deduce first-order necessary optimality conditions by studying the corresponding linearized system and the backward adjoint system.
Tipologia CRIS:
1.1 Articolo in rivista
Keywords:
Stochastic systems of partial differential equations / Cahn-Hilliard equation / optimal control, first-order necessary conditions / tumor growth
Elenco autori:
Orrieri, Carlo; Rocca, Elisabetta; Scarpa, Luca
Autori di Ateneo:
ORRIERI CARLO
ROCCA ELISABETTA
Link alla scheda completa:
https://iris.unipv.it/handle/11571/1361134
Pubblicato in:
ESAIM. COCV
Journal
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URL

https://www.esaim-cocv.org/articles/cocv/abs/2020/01/cocv190130/cocv190130.html
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