Data di Pubblicazione:
2006
Abstract:
Bradykinin (BK) is involved in a wide variety of pathophysiological processes. Potent BK peptide antagonists can be
developed introducing constrained unnatural amino acids, necessary to force the secondary structure of the molecule. In this paper,
we report a structure–activity relationship study of two peptide analogues of the potent B2 antagonist HOE 140 by replacing the
D-Tic-Oic dipeptide with conformationally constrained dipeptide mimetic b-turn inducers.
developed introducing constrained unnatural amino acids, necessary to force the secondary structure of the molecule. In this paper,
we report a structure–activity relationship study of two peptide analogues of the potent B2 antagonist HOE 140 by replacing the
D-Tic-Oic dipeptide with conformationally constrained dipeptide mimetic b-turn inducers.
Tipologia CRIS:
1.1 Articolo in rivista
Keywords:
Bicyclic lactam b-turn inducers; conformationally constrained peptidomimetics; Bradykinin antagonists
Elenco autori:
Alcaro Maria, C; Vinci, Valerio; D'Ursi Anna, M; Scrima, Mario; Chelli, Mario; Giuliani, Sandro; Meini, Stefania; DI GIACOMO, Marcello; Colombo, Lino; Papini Anna, Maria
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