mmpL7 gene of Mycobacterium tuberculosis is responsible for isoniazid efflux in Mycobacterium smegmatis
Articolo
Data di Pubblicazione:
2005
Abstract:
The Mycobacterium tuberculosis mmpL7 gene, encoding a hypothetical resistance nodulation division transporter,
confers a high resistance level to isoniazid when overexpressed in Mycobacterium smegmatis. The
resistance level decreased in the presence of the efflux pump inhibitors reserpine and CCCP (carbonyl cyanide
m-chlorophenylhydrazone). Energy-dependent efflux of isoniazid from M. smegmatis cells expressing the
mmpL7 gene was observed.
confers a high resistance level to isoniazid when overexpressed in Mycobacterium smegmatis. The
resistance level decreased in the presence of the efflux pump inhibitors reserpine and CCCP (carbonyl cyanide
m-chlorophenylhydrazone). Energy-dependent efflux of isoniazid from M. smegmatis cells expressing the
mmpL7 gene was observed.
Tipologia CRIS:
1.1 Articolo in rivista
Keywords:
mmpL7; Mycobacterium tuberculosis; efflux pump; drug resistance; isoniazid
Elenco autori:
Pasca, MARIA ROSALIA; Guglierame, Paola; DE ROSSI, Edda; Zara, Francesca; Riccardi, Giovanna
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