Age-related chances of mitochondrial cytochrome C oxidase and F(0)F(1)-ATP synthase subunit contents in rat cerebral cortex

The levels of subunits I, II/III, and IV of cytochrome c oxidase and of subunits alpha. beta and gamma of F(0)F(1)-ATP synthase in inner mitochondrial membrane proteins purified from cerebral cortex of rat at 2, 6, 12, 18, 24, 26 months of age were analyzed by Western blot. Age-related changes in the content of subunits, encoded either in mitochondrial or nuclear DNA, were observed