Data di Pubblicazione:
2021
Abstract:
Objectives: The immunologic profile and opportunistic viral DNA increase were monitored in Italian patients with COVID-19 in order to identify markers of disease severity. Methods: A total of 104 patients infected with SARS-CoV-2 were evaluated in the study. Of them, 42/104 (40.4%) were hospitalized in an intensive care unit (ICU) and 62/104(59.6%) in a sub-intensive care unit (SICU). Human cytomegalovirus (HCMV) and Epstein-Barr virus (EBV), Parvovirus B19 and Human Herpesvirus 6 virus reactivations were determined by real-time PCR, and lymphocyte subpopulation counts were determined by flow cytometry. Results: Among opportunistic viruses, only EBV was consistently detected. EBV DNA was observed in 40/42 (95.2%) of the ICU patients and in 51/61 (83.6%) of the SICU patients. Comparing the two groups of patients, the EBV DNA median level among ICU patients was significantly higher than that observed in SICU patients. In parallel, a significant reduction of CD8 T cell and NK count in ICU patients as compared with SICU patients was observed (p < 0.05). In contrast, B cell count was significantly increased in ICU patients (p = 0.0172). Conclusions: A correlation between reduced CD8+ T cells and NK counts, EBV DNA levels and COVID-19 severity was observed. Other opportunistic viral infections were not observed. The relationship between EBV load and COVID-19 severity should be further evaluated in longitudinal studies.
Tipologia CRIS:
1.1 Articolo in rivista
Keywords:
COVID-19; EBV DNA; Lymphocyte subpopulation
Elenco autori:
Paolucci, S.; Cassaniti, I.; Novazzi, F.; Fiorina, L.; Piralla, A.; Comolli, G.; Bruno, R.; Maserati, R.; Gulminetti, R.; Novati, S.; Mojoli, F.; Baldanti, F.; Bruno, R.; Mondelli, M.; Brunetti, E.; Di Matteo, A.; Seminari, E.; Maiocchi, L.; Zuccaro, V.; Pagnucco, L.; Mariani, B.; Ludovisi, S.; Lissandrin, R.; Parisi, A.; Sacchi, P.; Patruno, S. F. A.; Michelone, G.; Gulminetti, R.; Zanaboni, D.; Novati, S.; Maserati, R.; Orsolini, P.; Vecchia, M.; Sciarra, M.; Asperges, E.; Colaneri, M.; Di Filippo, A.; Sambo, M.; Biscarini, S.; Lupi, M.; Roda, S.; Pieri, T. C.; Gallazzi, I.; Sachs, M.; Valsecchi, P.; Perlini, S.; Alfano, C.; Bonzano, M.; Briganti, F.; Crescenzi, G.; Falchi, A. G.; Guarnone, R.; Guglielmana, B.; Maggi, E.; Martino, I.; Pettenazza, P.; Pioli di Marco, S.; Quaglia, F.; Sabena, A.; Salinaro, F.; Speciale, F.; Zunino, I.; De Lorenzo, M.; Secco, G.; Dimitry, L.; Cappa, G.; Maisak, I.; Chiodi, B.; Sciarrini, M.; Barcella, B.; Resta, F.; Moroni, L.; Vezzoni, G.; Scattaglia, L.; Boscolo, E.; Zattera, C.; Tassi, M. F.; Capozza, V.; Vignaroli, D.; Bazzini, M.; Iotti, G.; Mojoli, F.; Belliato, M.; Perotti, L.; Mongodi, S.; Tavazzi, G.; Marseglia, G.; Licari, A.; Brambilla, I.; Barbarini, D.; Bruno, A.; Cambieri, P.; Campanini, G.; Cavanna, C.; Comolli, G.; Corbella, M.; Daturi, R.; Furione, M.; Marone, P.; Monzillo, E.; Paolucci, S.; Parea, M.; Percivalle, E.; Piralla, A.; Rovida, F.; Sarasini, A.; Zavattoni, M.; Adzasehoun, G.; Ardizzone, M.; Bellotti, L.; Brunco, V.; Cabano, E.; Casali, G.; Capella, L.; Devitis, D.; Dossena, L.; Frisco, G.; Garbagnoli, G.; Gardellini, F.; Girello, A.; Guerrizio, A.; Landini, V.; Lucchelli, C.; Maliardi, V.; Piemontese, P.; Pezzaia, S.; Premoli, M.; Rebuffa, C.; Zanello, C.; Bagnarino, J.; Bergami, F.; Bonetti, A.; Caneva, G.; Cassaniti, I.; Corcione, A.; Di Martino, R.; Di Napoli, A.; Ferrari, A.; Ferrari, G.; Fiorina, L.; Gallone, A.; Giardina, F.; Girardi, A.; Mercato, A.; Merla, C.; Novazzi, F.; Ratano, G.; Rossi, B.; Saveriaempillai, G.; Sciabica, I. M.; Tallarita, M.; Vecchio Nepita, E.; Vitali, J.; Cerino, A.; Varchetta, S.; Oliviero, B.; Mantovani, S.; Mele, D.; Calvi, M.; Tizzoni, M.; Nicora, C.; Triarico, A.; Petronella, V.; Marena, C.; Muzzi, A.; Lago, P.; Cutti, S.; Novelli, V.; Comandatore, F.; Batistibiffignandi, G.; Gaiarsa, S.; Rettani, M.; Bandi, C.; Bruno, Raffele
Link alla scheda completa:
Link al Full Text:
Pubblicato in: