Mutational and immunogenetic landscape of HCV-associated B-cell lymphoproliferative disorders

In summary, to the best of our knowledge, this was the first study that explored by means of an extensive targeted NGS panel the muta- tional profile of HCV-associated B-cell LPDs, identifying recurrently mutated genes and pathways. Our results demonstrate also that a subset of HCV-related LPDs may harbor distinct molecular and immu- nogenetic features and bring out the potential correlation between specific BCR configurations, genetic lesions and regression of the lymphoproliferation after HCV eradication. A clinical trial with DAAs in indolent HCV-positive lymphomas is ongoing with ancillary biologi- cal studies and will provide further data in this setting (NCT02836925).