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COVID-19-Associated Subacute Thyroiditis: Evidence-Based Data From a Systematic Review

Articolo
Data di Pubblicazione:
2021
Abstract:
Subacute thyroiditis (SAT) is a thyroid disease of viral or post-viral origin. Whether SAT represents a complication of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is still unclear. Our aim was to systematically review the literature to 1) explore the size of the literature about SAT in COVID-19 and 2) evaluate the clinical characteristics of SAT. PubMed/MEDLINE, Embase, and Scopus were searched until April 20, 2021. Original papers, case reports, and case series reporting SAT in COVID-19 patients were included. Authors and their country, journal, year of publication, COVID-19 and SAT clinical presentation, thyroid function, therapy, and follow-up data were extracted. Nineteen papers (17 case reports and 2 case series) were included, describing 27 patients, 74.1% females, aged 18 to 69 years. COVID-19 was diagnosed by nasopharyngeal swab in 66.7% cases and required hospitalization in 11.1%. In 83.3% cases, SAT occurred after COVID-19. Neck pain was present in 92.6% cases and fever in 74.1%. Median TSH, fT3, and fT4 were 0.01 mU/l, 10.79 pmol/l, and 27.2 pmol/l, respectively. C-reactive-protein and erythrocyte sedimentation rate were elevated in 96% of cases. Typical ultrasonographic characteristics of SAT were observed in 83.3% of cases. Steroids were the most frequent SAT therapy. Complete remission of SAT was recorded in most cases. In conclusion, the size and quality of published data of SAT in COVID-19 patients are poor, with only case reports and case series being available. SAT clinical presentation in COVID-19 patients seems to be similar to what is generally expected.
Tipologia CRIS:
1.1 Articolo in rivista
Keywords:
COVID-19; SARS-CoV-2; subacute thyroiditis (SAT); subacute thyroiditis de Quervain; thyroid; Adolescent; Adult; Aged; COVID-19; Evidence-Based Medicine; Female; Humans; Male; Middle Aged; Thyroiditis, Subacute; Young Adult
Elenco autori:
Trimboli, P.; Cappelli, C.; Croce, L.; Scappaticcio, L.; Chiovato, L.; Rotondi, M.
Autori di Ateneo:
CROCE LAURA
ROTONDI MARIO
Link alla scheda completa:
https://iris.unipv.it/handle/11571/1450703
Pubblicato in:
FRONTIERS IN ENDOCRINOLOGY
Journal
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