The relevance of symptom perception in the management of severe asthma in adolescents

Background. Severe asthma in adolescents is a demanding challenge that deserves adequate management, including thorough work-up and rigorous follow-up. Methods. We evaluated a group of adolescents with severe asthma to investigate the change over time of clinical, functional, and biological parameters. Results. Most of adolescents treated with standard therapy improved, but some did not achieve an optimal asthma control and FeNO values increased. Conclusions. Despite guidelines-based therapy and clinical-functional improvement, type 2 inflammation could be not completely controlled. Biologics option could be considered if biomarkers suggest potential asthma relapse.