Phosphorylation of 10-bromoanthracen-9-yl-cyclopenta[d]isoxazol-6-ols: chemistry suitable for antivirals

Regioisomeric nor-nucleoside analogues, brominated at the anthracene ring, have been prepared and phosphorylated according to different protocols affording a variety of phosphate and phosphonate derivatives. Chiral phosphorus derivatives were also obtained as inseparable mixtures of diastereisomers. The synthetic methods are described and found to be reliable and robust, affording nor-nucleosides and nornucleotides, available in large amounts for in vitro antiviral evaluation.