Multinational characterization of neurological phenotypes in patients hospitalized with COVID-19
Articolo
Data di Pubblicazione:
2021
Abstract:
Neurological complications worsen outcomes in COVID-19. To define the prevalence of neurological conditions among hospitalized patients with a positive SARS-CoV-2 reverse transcription polymerase chain reaction test in geographically diverse multinational populations during early pandemic, we used electronic health records (EHR) from 338 participating hospitals across 6 countries and 3 continents (January-September 2020) for a cross-sectional analysis. We assessed the frequency of International Classification of Disease code of neurological conditions by countries, healthcare systems, time before and after admission for COVID-19 and COVID-19 severity. Among 35,177 hospitalized patients with SARS-CoV-2 infection, there was an increase in the proportion with disorders of consciousness (5.8%, 95% confidence interval [CI] 3.7-7.8%, p(FDR) < 0.001) and unspecified disorders of the brain (8.1%, 5.7-10.5%, p(FDR) < 0.001) when compared to the pre-admission proportion. During hospitalization, the relative risk of disorders of consciousness (22%, 19-25%), cerebrovascular diseases (24%, 13-35%), nontraumatic intracranial hemorrhage (34%, 20-50%), encephalitis and/or myelitis (37%, 17-60%) and myopathy (72%, 67-77%) were higher for patients with severe COVID-19 when compared to those who never experienced severe COVID-19. Leveraging a multinational network to capture standardized EHR data, we highlighted the increased prevalence of central and peripheral neurological phenotypes in patients hospitalized with COVID-19, particularly among those with severe disease.
Tipologia CRIS:
1.1 Articolo in rivista
Elenco autori:
Trang T., Le; Gutiérrez-Sacristán, Alba; Son, Jiyeon; Hong, Chuan; South, Andrew M.; Beaulieu-Jones, Brett K.; Loh, Ne Hooi Will; Luo, Yuan; Morris, Michele; Ngiam, Kee Yuan; Patel, Lav P.; Samayamuthu, Malarkodi J.; Schriver, Emily; Tan, Amelia L. M.; Moore, Jason; Cai, Tianxi; Omenn, Gilbert S.; Avillach, Paul; Kohane, Isaac S.; Aaron, James R.; Agapito, Giuseppe; Albayrak, Adem; Alessiani, Mario; Amendola, Danilo F.; Angoulvant, François; Anthony, Li L. L. J.; Aronow, Bruce J.; Atz, Andrew; Balshi, James; Bell, Douglas S.; Bellasi, Antonio; Bellazzi, Riccardo; Vincent, Benoit; Beraghi, Michele; Bernal Sobrino, José Luis; Bernaux, Mélodie; Bey, Romain; Blanco Martínez, Alvar; Boeker, Martin; Bonzel, Clara-Lea; Booth, John; Bosari, Silvano; Bourgeois, Florence T.; Bradford, Robert L.; Brat, Gabriel A.; Bréant, Stéphane; Brown, Nicholas W.; Bryant, William A.; Bucalo, Mauro; Burgun, Anita; Cannataro, Mario; Carmona, Aldo; Caucheteux, Charlotte; Champ, Julien; Chen, Krista; Chen, Jin; Chiovato, Luca; Chiudinelli, Lorenzo; Cimino, James J.; Colicchio, Tiago K.; Cormont, Sylvie; Cossin, Sébastien; Craig, Jean B.; Cruz Bermúdez, Juan Luis; Cruz Rojo, Jaime; Dagliati, Arianna; Daniar, Mohamad; Daniel, Christel; Davoudi, Anahita; Devkota, Batsal; Dubiel, Julien; Esteve, Loic; Fan, Shirley; Follett, Robert W.; Gaiolla, Paula S. A.; Ganslandt, Thomas; García Barrio, Noelia; Garmire, Lana X.; Gehlenborg, Nils; Geva, Alon; Gradinger, Tobias; Gramfort, Alexandre; Griffier, Romain; Griffon, Nicolas; Grisel, Olivier; Hanauer, David A.; Haverkamp, Christian; Bing, He; Henderson, Darren W.; Hilka, Martin; Holmes, John H.; Horki, Petar; Huling, Kenneth M.; Hutch, Meghan R.; Issitt, Richard W.; Jannot, Anne Sophie; Jouhet, Vianney; Kavuluru, Ramakanth; Keller, Mark S.; Kirchoff, Katie; Klann, Jeffrey G.; Krantz, Ian D.; Kraska, Detlef; Krishnamurthy, Ashok K.; L’Yi, Sehi; Leblanc, Judith; Leite, Andressa R. R.; Lemaitre, Guillaume; Lenert, Leslie; Leprovost, Damien; Liu, Molei; Lozano-Zahonero, Sarah; Lynch, Kristine E.; Mahmood, Sadiqa; Maidlow, Sarah; Makoudjou Tchendjou, Adeline C.; Malovini, Alberto; Mandl, Kenneth D.; Mao, Chengsheng; Maram, Anupama; Martel, Patricia; Masino, Aaron J.; Matheny, Michael E.; Maulhardt, Thomas; Mazzitelli, Maria; Mcduffie, Michael T.; Mensch, Arthur; Ashraf, Fatima; Milano, Marianna; Minicucci, Marcos F.; Moal, Bertrand; Moraleda, Cinta; Morris, Jeffrey S.; Moshal, Karyn L.; Mousavi, Sajad; Murad, Douglas A.; Murphy, Shawn N.; Naughton, Thomas P.; Neuraz, Antoine; Norman, James B.; Obeid, Jihad; Okoshi, Marina P.; Olson, Karen L.; Orlova, Nina; Ostasiewski, Brian D.; Palmer, Nathan P.; Paris, Nicolas; Pedrera Jimenez, Miguel; Pfaff, Emily R.; Pillion, Danielle; Prokosch, Hans U.; Prudente, Robson A.; Quirós González, Víctor; Ramoni, Rachel B.; Raskin, Maryna; Rieg, Siegbert; Roig Domínguez, Gustavo; Rojo, Pablo; Sáez, Carlos; Salamanca, Elisa; Sandrin, Arnaud; Santos, Janaina C. C.; Savino, Maria; Schuettler, Juergen; Scudeller, Luigia; Sebire, Neil J.; Balazote, Pablo Serrano; Serre, Patricia; Serret-Larmande, Arnaud; Shakeri, Zahra; Silvio, Domenick; Sliz, Piotr; Sonday, Charles; Spiridou, Anastasia; Tan, Bryce W. Q.; Tan, Byorn W. L.; Tanni, Suzana E.; Taylor, Deanne M.; Terriza-Torres, Ana I.; Tibollo, Valentina; Tippmann, Patric; Torti, Carlo; Trecarichi, Enrico M.; Tseng, Yi-Ju; Vallejos, Andrew K.; Varoquaux, Gael; Vella, Margaret; Vie, Jill-Jênn; Vitacca, Michele; Wagholikar, Kavishwar B.; Waitman, Lemuel R.; Wassermann, Demian; Weber, Griffin M.; William, Yuan; Yehya, Nadir; Zambelli, Alberto; Zhang, Harrison G.; Zoeller, Daniela; Zucco, Chiara; Visweswaran, Shyam; Mowery, Danielle L.; Xia, Zongqi; Null, Null
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