Clinical features and comorbidity pattern of HCV infected migrants compared to native patients in care in Italy: A real-life evaluation of the PITER cohort
Articolo
Data di Pubblicazione:
2021
Abstract:
Background: Direct-acting antivirals are highly effective for the treatment of hepatitis C virus (HCV) infection, regardless race/ethnicity. We aimed to evaluate demographic, virological and clinical data of HCV-infected migrants vs. natives consecutively enrolled in the PITER cohort. Methods: Migrants were defined by country of birth and nationality that was different from Italy. Mann-Whitney U test, Chi-squared test and multiple logistic regression were used. Results: Of 10,669 enrolled patients, 301 (2.8%) were migrants: median age 47 vs. 62 years, (p < 0.001), females 56.5% vs. 45.3%, (p < 0.001), HBsAg positivity 3.8% vs. 1.4%, (p < 0.05). Genotype 1b was prevalent in both groups, whereas genotype 4 was more prevalent in migrants (p < 0.05). Liver disease severity and sustained virologic response (SVR) were similar. A higher prevalence of comorbidities was reported for natives compared to migrants (p < 0.05). Liver disease progression cofactors (HBsAg, HIV coinfection, alcohol abuse, potential metabolic syndrome) were present in 39.1% and 47.1% (p > 0.05) of migrants and natives who eradicated HCV, respectively. Conclusion: Compared to natives, HCV-infected migrants in care have different demographics, HCV genotypes, viral coinfections and comorbidities and similar disease severity, SVR and cofactors for disease progression after HCV eradication. A periodic clinical assessment after HCV eradication in Italians and migrants with cofactors for disease progression is warranted.
Tipologia CRIS:
1.1 Articolo in rivista
Keywords:
Comorbidities; Direct acting antivirals; HCV Cohort; Linked-to-care patients
Elenco autori:
Quaranta, Maria Giovanna; Ferrigno, Luigina; Tata, Xhimi; D'Angelo, Franca; Massari, Marco; Coppola, Carmine; Biliotti, Elisa; Giorgini, Alessia; Laccabue, Diletta; Ciancio, Alessia; Blanc, Pier Luigi; Margotti, Marzia; Ieluzzi, Donatella; Brunetto, Maurizia Rossana; Barbaro, Francesco; Russo, Francesco Paolo; Beretta, Ilaria; Morsica, Giulia; Verucchi, Gabriella; Saracino, Annalisa; Galli, Massimo; Kondili, Loeta A.; Mazzaro, Cesare; Bertola, Manuela; Schioppa, Ornella; Benedetti, Antonio; Schiadà, Laura; Cucco, Monica; Giacometti, Andrea; Brescini, Laura; Castelletti, Sefora; Fiorentini, Alessandro; Angarano, Gioacchino; Milella, Michele; Di Leo, Alfredo; Rendina, Maria; D'Abramo, Fulvio Salvatore; Lillo, Chiara; Iannone, Andrea; Piazzolla, Mariano; Verucchi, Gabriella; Badia, Lorenzo; Piscaglia, Fabio; Benevento, Francesca; Serio, Ilaria; Castelli, Francesco; Zaltron, Serena; Spinetti, Angiola; Odolini, Silvia; Bruno, Raffaele; Mondelli, Mario; Chessa, Luchino; Loi, Martina; Torti, Carlo; Costa, Chiara; Mazzitelli, Maria; Pisani, Vincenzo; Scaglione, Vincenzo; Trecarichi, Enrico Maria; Zignego, Anna Linda; Monti, Monica; Madia, Francesco; Blanc, Pier Luigi; Attala, Letizia; Pierotti, Piera; Salomoni, Elena; Mariabelli, Elisa; Santantonio, Teresa Antonia; Bruno, Serena Rita; Cela, Ester Marina; Bassetti, Matteo; Mazzarello, Giovanni; Alessandrini, Anna Ida; Di Biagio, Antonio; Nicolini, Laura Ambra; Raimondo, Giovanni; Filomia, Roberto; Aghemo, Alessio; Meli, Rossella; Lazzarin, Adriano; Morsica, Giulia; Salpietro, Stefania; Galli, Massimo; Fracanzani, Anna Ludovica; Fatta, Erika; Lombardi, Rosa; Lampertico, Pietro; Borghi, Marta; D'Ambrosio, Roberta; Degasperi, Elisabetta; Puoti, Massimo; Baiguera, Chiara; D'Amico, Federico; Vinci, Maria; Rumi, Maria Grazia; Zuin, Massimo; Giorgini, Alessia; Zermiani, Paola; Andreone, Pietro; Caraceni, Paolo; Margotti, Marzia; Guarneri, Valeria; Villa, Erica; Bernabucci, Veronica; Bristot, Laura; Paradiso, Maria Luisa; Migliorino, Guglielmo; Beretta, Ilaria; Gambaro, Alessandra; Lapadula, Giuseppe; Spolti, Anna; Soria, Alessandro; Invernizzi, Pietro; Ciaccio, Antonio; Lucà, Martina; Malinverno, Federica; Ratti, Laura; Coppola, Carmine; Amoruso, Daniela Caterina; Pisano, Federica; Scarano, Ferdinando; Staiano, Laura; Morisco, Filomena; Cossiga, Valentina; Gentile, Ivan; Buonomo, Antonio Riccardo; Foggia, Maria; Zappulo, Emanuela; Federico, Alessandro; Dallio, Marcello; Coppola, Nicola; Sagnelli, Caterina; Martini, Salvatore; Monari, Caterina; Nardone, Gerardo; Sgamato, Costantino; Chemello, Liliana; Cavalletto, Luisa; Sterrantino, Daniela; Russo, Francesco Paolo; Zanetto, Alberto; Zanaga, Paola; Barbaro, Francesco; Brancaccio, Giuseppina; Craxì, Antonio; Petta, Salvatore; Calvaruso, Vincenza; Crapanzano, Luciano; Madonia, Salvatore; Cannizzaro, Marco; Bruno, Erica Maria; Licata, Anna; Amodeo, Simona; Capitano, Adele Rosaria; Ferrari, Carlo; Laccabue, Diletta; Negri, Elisa; Orlandini, Alessandra; Pesci, Marco; Gulminetti, Roberto; Pagnucco, Layla; Parruti, Giustino; Di Stefano, Paola; Brunetto, Maurizia Rossana; Coco, Barbara; Massari, Marco; Corsini, Romina; Garlassi, Elisa; Andreoni, Massimo; Teti, Elisabetta; Cerva, Carlotta; Baiocchi, Lorenzo; Tata, Xhimi; Grassi, Giuseppe; Gasbarrini, Antonio; Pompili, Maurizio; De Siena, Martina; Taliani, Gloria; Biliotti, Elisa; Spaziante, Martina; Persico, Marcello; Masarone, Mario; Aglitti, Andrea; Calvanese, Gemma; Anselmo, Marco; De Leo, Pasqualina; Marturano, Monica; Saracco, Giorgio Maria; Ciancio, Alessia; Ieluzzi, Donatella
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