The effect of newly diagnosed undifferentiated connective tissue disease on pregnancy outcome
Articolo
Data di Pubblicazione:
2008
Abstract:
OBJECTIVE: The purpose of this study was to evaluate pregnancy outcome in a cohort of patients with newly diagnosed undifferentiated connective tissue disease (UCTD).
STUDY DESIGN: We conducted a nested case-control study that compared 41 patients who had early UCTD that was diagnosed at 11-14 weeks of pregnancy with 82 healthy control subjects.
RESULTS: During pregnancy, UCTD progressed to a definite connective tissue disease in 2 of 41 patients (4.9%). Sixteen of the 41 patients (39%) with UCTD tested positive for anti-Ro (SSA) antibodies. Compared with the control subjects, the women with UCTD had higher rates of small for gestational age (SGA; 12/40 vs 11/80; P = .05). The rate of complications of pregnancy (preterm delivery at
CONCLUSION: Pregnant patients with UCTD are at increased risk of SGA and complications of pregnancy.
STUDY DESIGN: We conducted a nested case-control study that compared 41 patients who had early UCTD that was diagnosed at 11-14 weeks of pregnancy with 82 healthy control subjects.
RESULTS: During pregnancy, UCTD progressed to a definite connective tissue disease in 2 of 41 patients (4.9%). Sixteen of the 41 patients (39%) with UCTD tested positive for anti-Ro (SSA) antibodies. Compared with the control subjects, the women with UCTD had higher rates of small for gestational age (SGA; 12/40 vs 11/80; P = .05). The rate of complications of pregnancy (preterm delivery at
CONCLUSION: Pregnant patients with UCTD are at increased risk of SGA and complications of pregnancy.
Tipologia CRIS:
1.1 Articolo in rivista
Elenco autori:
Spinillo, Arsenio; Beneventi, Fausta; Epis, O. M.; Montanari, Laura; Mammoliti, D.; Ramoni, Veronique; Di Silverio, E.; Alpini, C.; Caporali, Roberto; Montecucco, Carlomaurizio
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