Data di Pubblicazione:
2020
Abstract:
Interindividual clinical variability in the course of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is vast. We report that at least 101 of 987 patients with life-threatening coronavirus disease 2019 (COVID-19) pneumonia had neutralizing immunoglobulin G (IgG) autoantibodies (auto-Abs) against interferon-w (IFN-w) (13 patients), against the 13 types of IFN-a (36), or against both (52) at the onset of critical disease; a few also had auto-Abs against the other three type I IFNs. The auto-Abs neutralize the ability of the corresponding type I IFNs to block SARS-CoV-2 infection in vitro. These auto-Abs were not found in 663 individuals with asymptomatic or mild SARS-CoV-2 infection and were present in only 4 of 1227 healthy individuals. Patients with auto-Abs were aged 25 to 87 years and 95 of the 101 were men. A B cell autoimmune phenocopy of inborn errors of type I IFN immunity accounts for life-threatening COVID-19 pneumonia in at least 2.6% of women and 12.5% of men.
Tipologia CRIS:
1.1 Articolo in rivista
Elenco autori:
Bastard, Paul; Rosen, Lindsey B.; Zhang, Qian; Michailidis, Eleftherios; Hoffmann, Hans-Heinrich; Zhang, Yu; Dorgham, Karim; Philippot, Quentin; Rosain, Jérémie; Béziat, Vivien; Manry, Jérémy; Shaw, Elana; Haljasmägi, Liis; Peterson, Pärt; Lorenzo, Lazaro; Bizien, Lucy; Trouillet-Assant, Sophie; Dobbs, Kerry; De Jesus, Adriana Almeida; Belot, Alexandre; Kallaste, Anne; Catherinot, Emilie; Tandjaoui-Lambiotte, Yacine; Le Pen, Jeremie; Kerner, Gaspard; Bigio, Benedetta; Seeleuthner, Yoann; Yang, Rui; Bolze, Alexandre; Spaan, András N.; Delmonte, Ottavia M.; Abers, Michael S.; Aiuti, Alessandro; Casari, Giorgio; Lampasona, Vito; Piemonti, Lorenzo; Ciceri, Fabio; Bilguvar, Kaya; Lifton, Richard P.; Vasse, Marc; Smadja, David M.; Migaud, Mélanie; Hadjadj, Jérome; Terrier, Benjamin; Duffy, Darragh; Quintana-Murci, Lluis; Van De Beek, Diederik; Roussel, Lucie; Vinh, Donald C.; Tangye, Stuart G.; Haerynck, Filomeen; Dalmau, David; Martinez-Picado, Javier; Brodin, Petter; Nussenzweig, Michel C.; Boisson-Dupuis, Stéphanie; Rodríguez-Gallego, Carlos; Vogt, Guillaume; Mogensen, Trine H.; Oler, Andrew J.; Gu, Jingwen; Burbelo, Peter D.; Cohen, Jeffrey I.; Biondi, Andrea; Bettini, Laura Rachele; D'Angio, Mariella; Bonfanti, Paolo; Rossignol, Patrick; Mayaux, Julien; Rieux-Laucat, Frédéric; Husebye, Eystein S.; Fusco, Francesca; Ursini, Matilde Valeria; Imberti, Luisa; Sottini, Alessandra; Paghera, Simone; Quiros-Roldan, Eugenia; Rossi, Camillo; Castagnoli, Riccardo; Montagna, Daniela; Licari, Amelia; Marseglia, Gian Luigi; Duval, Xavier; Ghosn, Jade; Null, Null; Null, Null; Null, Null; Null, Null; Null, Null; Null, Null; Null, Null; Null, Null; Null, Null; Null, Null; Tsang, John S.; Goldbach-Mansky, Raphaela; Kisand, Kai; Lionakis, Michail S.; Puel, Anne; Zhang, Shen-Ying; Holland, Steven M.; Gorochov, Guy; Jouanguy, Emmanuelle; Rice, Charles M.; Cobat, Aurélie; Notarangelo, Luigi D.; Abel, Laurent; Su, Helen C.; Casanova, Jean-Laurent; Arias, Andrés Augusto; Boisson, Bertrand; Boucherit, Soraya; Bustamante, Jacinta; Chbihi, Marwa; Chen, Jie; Chrabieh, Maya; Kochetkov, Tatiana; Le Voyer, Tom; Liu, Dana; Nemirovskaya, Yelena; Ogishi, Masato; Papandrea, Dominick; Patissier, Cécile; Rapaport, Franck; Roynard, Manon; Vladikine, Natasha; Woollett, Mark; Zhang, Peng; Kashyap, Anuj; Ding, Li; Bosticardo, Marita; Wang, Qinlu; Ochoa, Sebastian; Liu, Hui; Chauvin, Samuel D.; Stack, Michael; Koroleva, Galina; Bansal, Neha; Dalgard, Clifton L.; Snow, Andrew L.; Abad, Jorge; Aguilera-Albesa, Sergio; Akcan, Ozge Metin; Darazam, Ilad Alavi; Aldave, Juan C.; Ramos, Miquel Alfonso; Nadji, Seyed Alireza; Alkan, Gulsum; Allardet-Servent, Jerome; Allende, Luis M.; Alsina, Laia; Alyanakian, Marie-Alexandra; Amador-Borrero, Blanca; Amoura, Zahir; Antolí, Arnau; Arslan, Sevket; Assant, Sophie; Auguet, Terese; Azot, Axelle; Bajolle, Fanny; Baldolli, Aurélie; Ballester, Maite; Feldman, Hagit Baris; Barrou, Benoit; Beurton, Alexandra; Bilbao, Agurtzane; Blanchard-Rohner, Geraldine; Blanco, Ignacio; Blandinières, Adeline; Blazquez-Gamero, Daniel; Bloomfield, Marketa; Bolivar-Prados, Mireia; Borie, Raphael; Bousfiha, Ahmed A.; Bouvattier, Claire; Boyarchuk, Oksana; Bueno, Maria Rita P.; Bustamante, Jacinta; Cáceres Agra, Juan José; Calimli, Semra; Capra, Ruggero; Carrabba, Maria; Casasnovas, Carlos; Caseris, Marion; Castelle, Martin; Castelli, Francesco; De Vera, Martín Castillo; Castro, Mateus V.; Catherinot, Emilie; Chalumeau, Martin; Charbit, Bruno; Cheng, Matthew P.; Clavé, Père; Clotet, Bonaventura; Codina, Anna; Colkesen, Fatih; Colkesen, Fatma; Colobran, Roger; Comarmond, Cloé; Corsico, Angelo G.; Dalmau, David; Darley, David Ross; Dauby, Nicolas; Dauger, Stéphane; De Pontual, Loic; Dehban, Amin; Delplancq, Geoffroy; Demoule, Alexandre; Di Sabatino, Antonio; Diehl, Jean-Luc; Dobbelaere, Stephanie; Durand, Sophie; Eldars, Waleed; Elgamal, Mohamed; Elnagdy, Marwa H.; Emiroglu, Melike; Erdeniz, Emine Hafize; Aytek
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