A preliminary study of chitosan-pentosan polysulfate sodium complex as vaginal sustained drug delivery system in a rare disease treatment
Articolo
Data di Pubblicazione:
2010
Abstract:
Pentosan polysulphate sodium (PPS) is the only oral medicine
(Elmiron®) FDA approved for treating interstitial cystitis (IC), a rare
disease results in recurring discomfort, pressure, tenderness, or
intense pain in the bladder and pelvic area.
The aim of this work was to develop a new therapeutic system,
able to deliver PPS directly to vaginal area, by ionotropic gelation
between the polyanionic PPS and polycationic chitosan.
(Elmiron®) FDA approved for treating interstitial cystitis (IC), a rare
disease results in recurring discomfort, pressure, tenderness, or
intense pain in the bladder and pelvic area.
The aim of this work was to develop a new therapeutic system,
able to deliver PPS directly to vaginal area, by ionotropic gelation
between the polyanionic PPS and polycationic chitosan.
Tipologia CRIS:
1.1 Articolo in rivista
Keywords:
Chitosan pentosan; Rare disease; Interstitial cystitis
Elenco autori:
Raspagni, A.; Perugini, Paola; Porru, D.; Pavanetto, Franca
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