Data di Pubblicazione:
1986
Abstract:
Seven clinical isolates of Enterobacteriaceae resistant to third-generation cephalosporins were investigated in order to assess the role played in resistance by permeability barrier and by beta-lactamase production. The addition of subinhibitory concentrations of EDTA increased susceptibility to ceftriaxone in five strains showing that the permeability barrier is involved. All strains produced different amounts of beta-lactamases that were always increased by cefoxitin induction. Hydrolytic activity of investigated enzymes varied in different cephalosporins; ceftriaxone and ceftazidime are the most stable compounds.
Tipologia CRIS:
1.1 Articolo in rivista
Keywords:
Cephalosporins; pharmacology, Drug Resistance; Microbial, Enterobacteriaceae; drug effects/isolation /&/ purification, Humans, Microbial Sensitivity Tests, Species Specificity, Structure-Activity Relationship, beta-Lactamases; metabolism
Elenco autori:
Perduca, Margherita; Pagani, Laura; Cereda, PAOLO MARTINO; Debiaggi, Maurizia
Link alla scheda completa:
Pubblicato in: