[Cardiodynamic changes induced with dilazep in chronic coronary insufficiency]

Systolic intervals, heart rate (HR) and blood pressure (BP) were monitored before and after oral administration of dilazep in 28 patients with chronic coronary disease. Controls were performed before drug assumption and after two months of treatment. 16 patients were given dilazep in 100 mg doses three times a day; 12 patients in 50 mg doses three times a day. In the former group dilazep brought about a PEP reduction owing to a shortening of the isovolumic contraction time. Also we noticed a constant decrease of BP, both systolic and diastolic, the former tapering from 155 down to 143 mmHg, the latter from 88 to 81. In the 12 patients treated with 150 mg a day, we did not notice any relevant alteration relatable to the drug since systolic intervals and BP were unimpaired. These observations point to a positive inotropic effect and a moderate vasodilatatory effect caused by dilazep if administered in 300 mg doses a day