Initial bone marrow reticulin fibrosis in polycythemia vera exerts an impact on clinical outcome.
Articolo
Data di Pubblicazione:
2012
Abstract:
We examined the prevalence and prognostic relevance of bone marrow reticulin fibrosis in 526 patients with World Health Organization-defined polycythemia vera evaluated at the time of initial diagnosis. Seventy-four patients (14%) displayed mostly grade 1 reticulin fibrosis, with only 2 cases showing higher-grade fibrosis. Presenting clinical and laboratory characteristics, including JAK2V617F allele burden, between patients with and without fibrosis were similar for the most part, with the exception of a higher prevalence of palpable splenomegaly in patients with fibrosis (P < .01). Patients with fibrosis were less prone to experience thrombosis during their clinical course (1.1 vs 2.7 per 100 patient-years; P = .03) and more prone to develop post-polycythemia vera myelofibrosis (2.2 vs 0.8 per 100 patient-years; P = .01). There was no significant difference between the 2 groups in terms of overall or leukemia-free survival. The present study clarifies the incidence, degree, and prognostic relevance of bone marrow fibrosis obtained at time of initial diagnosis of polycythemia vera.
Tipologia CRIS:
1.1 Articolo in rivista
Keywords:
fibrosis; polycythemia; outcome
Elenco autori:
Barbui, T; Thiele, J; Passamonti, F; Rumi, Elisa; Boveri, E; Randi, Ml; Bertozzi, I; Marino, F; Vannucchi, Am; Pieri, L; Rotunno, G; Gisslinger, H; Gisslinger, B; Müllauer, L; Finazzi, G; Carobbio, A; Gianatti, A; Ruggeri, M; Nichele, I; D'Amore, E; Rambaldi, A; Tefferi, A.
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