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Acute phase proteins and prognosis in multiple myeloma.

Articolo
Data di Pubblicazione:
1993
Abstract:
Serum IL-6 levels have been shown to correlate with disease severity and prognosis in patients with plasma cell dyscrasias. Among its pleiotropic actions, IL-6 is also the major regulator of the acute phase response in humans. The possible impact on survival of the major serum acute phase proteins (s.APP) [C-reactive protein (s.CRP), alpha-1-antitrypsin (s.AAT), haptoglobin, acid alpha-1-glycoprotein and alpha-2-macroglobulin (used as control)] was assessed on a population of 103 consecutive, previously untreated myeloma patients. Univariate analysis showed that among the acute phase proteins only s.AAT (P = 0.015) and s.CRP (P = 0.027) were significantly correlated with survival. The multivariate Cox proportional hazard model applied to s.APP and other common parameters showed that s.beta-2-microglobulin (s.b2M), s.calcium, s.creatinine, BM plasma cell percentage, age and s.AAT correlated significantly with survival. Combining s.b2M and s.AAT allowed stratification of myeloma patients: those with low levels of s.b2M (< or = 3 mg/l) and of s.AAT (< or = 3 g/l) presented an excellent prognosis (median survival exceeding 10 years) while those presenting higher values of the two parameters presented a median survival of 2.5 years (P = 0.002).
Tipologia CRIS:
1.1 Articolo in rivista
Keywords:
statistical analysis; myeloma; s.AAT
Elenco autori:
Merlini, Giampaolo; Perfetti, V.; Gobbi, P. G.; Quaglini, Silvana; Franciotta, D. M.; Marinone, G.; Ascari, Edoardo
Autori di Ateneo:
MERLINI GIAMPAOLO
QUAGLINI SILVANA
Link alla scheda completa:
https://iris.unipv.it/handle/11571/464215
Pubblicato in:
BRITISH JOURNAL OF HAEMATOLOGY
Journal
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