Solid state microcalorimetry on drug-cyclodextrin binary systems

Differential scanning Calorimetry DSC has been applied to the analysis of drug-cyclodextrin binary systems in order to gain experimental evidence of the interaction and determine the stoichiometry of the inclusion compound. Two model systems, paracetamol-betacyclodextrin and vinburnine-gammacyclodextrin were tested through the comparison of thermal behaviors of interacted and non-interacted mixtures containing excess drug. DSC allowed a confirmation of both interaction and stoichiometry of the inclusion compounds.