Experimental models for the study of migraine - State of the art and future developments

The possibility to investigate the mechanisms underlying migraine attacks in reliable animal models has yielded a considerable amount of data during recent years. The interpretation, if not the understanding of the very early events that are able to trigger the cascade of events that periodically constrain a considerable number of people in miserable conditions, has allowed the identification of the anatomical structures which are involved in the process and, at least partly, the mechanisms through which these structures are activated or act. The various animal models used by the different research groups are concisely presented along with the results that the researchers have collected.