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The ERCC2 Gln/Gln polymorphism at codon 751 is not associated with leukaemic transformation in primary myelofibrosis

Articolo
Data di Pubblicazione:
2013
Abstract:
The complexity of pathogenesis in PMF is indicated by the overwhelming greater number of mutation abnormalities other than JAK2 V617F and MPL W515 (Vainchenker et al, 2011); it is therefore intuitive that genetic processes leading to leukaemia in PMF may also differ from those in PV and ET. These reasoning may help to explain why in this study we failed to confirm a leukaemia-predisposing role of the CC ERCC2 polymorphism as reported in PV and ET.
Tipologia CRIS:
1.1 Articolo in rivista
Keywords:
Primary myelofibrosis; Acute leukemia
Elenco autori:
Susini, Mc; Guglielmelli, P; Spolverini, A; Biamonte, F; Mannarelli, C; Barosi, G; Zoi, K; Reiter, A; Duncombe, A; Cervantes, F; Cazzola, Mario; Cross, N; Vannucchi, Am
Link alla scheda completa:
https://iris.unipv.it/handle/11571/849447
Pubblicato in:
BRITISH JOURNAL OF HAEMATOLOGY
Journal
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URL

http://onlinelibrary.wiley.com/doi/10.1111/bjh.12376/full
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