Aryl ethynyl anthraquinones: a useful platform for targeting telomeric G-quadruplex structures
Articolo
Data di Pubblicazione:
2014
Abstract:
Aryl ethynyl anthraquinones have been synthesized by Sonogashira cross-coupling and evaluated as telomeric G-quadruplex ligands, by the FRET melting assay, circular dichroism, the DNA synthesis arrest assay and molecular docking. Both the binding properties and G-quadruplex vs. duplex selectivity are controlled by the structures of the aryl ethynyl moieties
Tipologia CRIS:
1.1 Articolo in rivista
Keywords:
Anthraquinones; Sonogashira cross-coupling; Nucleic acids; G-quadruplex structures
Elenco autori:
Percivalle, Claudia; Claudia, Sissi; Maria Laura, Greco; Caterina, Musetti; Mariani, Angelica; Anna, Artese; Giosuè, Costa; Maria Lucia, Perrore; Stefano, Alcaro; Freccero, Mauro
Link alla scheda completa:
Pubblicato in: