High Tc-99m-DPD myocardial uptake in a patient with apolipoprotein AI-related amyloidotic cardiomyopathy

Amyloidotic cardiomyopathy is still a widely underdiagnosed condition that usually requires endomyocardial biopsy (EMB) for a definite diagnosis. Tc-99m-3,3-diphosphono-1,2-propanodicarboxylic acid (Tc-99m-DPD) has proven highly sensitive for detecting amyloidotic cardiomyopathy due to transthyretin-related amyloid deposition. Herein we report the first description of the Tc-99m-DPD scintigraphy profile in a patient with suspected amyloidotic cardiomyopathy and a final EMB- and genetically-proven diagnosis of familial apolipoprotein AI amyloidosis due to Leu174Ser variant.