The course aims to deepen the experimental aspect of Organic Chemistry, completing the basic knowledge acquired previously with regard to the synthesis of organic molecules and experimental techniques.
Course Prerequisites
Having attended the Laboratory of Organic Chemistry
Teaching Methods
The course uses lectures for the explanation of experiences, followed by laboratory activities
Assessment Methods
The test consists of an oral exam that will focus on the experiences made in the laboratory and on the reports written by the student previously delivered
Texts
Vogel Chimica Organica Pratica Casa Editrice Ambrosiana - Milano D.L. Pavia, G.M. Lampman, G. S. Kriz Il Laboratorio di Chimica Organica Ed. Sorbona – Milano M. D’Ischia La Chimica Organica in Laboratorio Ed. Piccin
Contents
This objective will be achieved through laboratory experiences that use synthetic reactions learned in theoretical courses. The student will be directed to the evaluation of all aspects of a synthesis (optimization of yields, analysis of products with modern experimental techniques, safety of operations, etc.). Moreover it will explained how access to bibliographic information trough chemical databases
Here is reported the list of lab experiments: • Preparation of ethyl (E)-4-methoxy-cinnamate-esters by Horner–Wadsworth–Emmons reaction between 4-methoxy-benzaldeyde and trimethyl phosphoacetate in aqueous solvent • Reduction of Camphor to Borneol using Sodium Borohydride or Sodium metal • Nifedipine synthesis through Hantzsch reaction. • Photochemical reaction of Nifedipine monitored by HPLC analysis. • Aldol reaction between 2-acetylpiridine and 4-nitrobenzaldehyde • Synthesis of triphenylcarbinol by Grignard reaction between phenyl magnesium bromide and methyl benzoate. • Friedel-Crafts acylation of methylbenzene • Nitration of bromobenzene The reactions are monitored by TLC and the products are characterized by spectroscopic IR, NMR or UV-Vis analysis.
