ID:
506522
Duration (hours):
16
CFU:
2
SSD:
FARMACOLOGIA
Year:
2025
Overview
Date/time interval
Primo Semestre (01/10/2025 - 16/01/2026)
Syllabus
Course Objectives
The learning objectives of the course are: 1) understand the meaning of the primary pharmacokinetic parameters (distribution volume and clearance), bioavailability and secondary ones (elimination rate constant, half-life, etc). 2) Determine primary and secondary pharmacokinetics parameters from concentration-time data. 3) Understand the influence of the route of administration and the various therapeutic regimens on the plasma concentration-time profile and predict the effect on it of changes of clearance and volume of distribution and other specific patient characteristics. 4) Understand the role of pharmacokinetic drug monitoring in choosing the correct dosage regimen in the individual patient.
Course Prerequisites
Have some knowledge of chemistry, biology, biochemistry, anatomy, physiology and
basic mathematical notions already used in chemistry and physics courses. Students will have to
know some concepts of chemical kinetics, e.g. zero and first order processes, however taught in the course.
basic mathematical notions already used in chemistry and physics courses. Students will have to
know some concepts of chemical kinetics, e.g. zero and first order processes, however taught in the course.
Teaching Methods
Lectures carried out through presentations (PowerPoint) projected on the screen and possible further information using the blackboard.
Assessment Methods
The exam will be carried out together with the other DD&A modules in a single test. The evaluation will be carried out with a weighted average in relation to the number of credits of each part.
It will be a written examination consisting of multiple choice and open questions based on didactic material used in the course, carried out in the presence with a PC or other electronic device. As regards the PK&TDM module, students must answer 2 open questions and 8 MCQ or T/F questions in 20 minutes. Graphics is emphasized: students must know how to draw plasma concentration - time curves, etc.
It will be a written examination consisting of multiple choice and open questions based on didactic material used in the course, carried out in the presence with a PC or other electronic device. As regards the PK&TDM module, students must answer 2 open questions and 8 MCQ or T/F questions in 20 minutes. Graphics is emphasized: students must know how to draw plasma concentration - time curves, etc.
Texts
Laurence Brunton et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 13th Edition, New York McGraw-Hill, 2018.
Stephen H. Curry, Robin Whelpton, Introduction to Drug Disposition and Pharmacokinetics 2017 John Wiley & Sons, Ltd.
Stephen H. Curry, Robin Whelpton, Introduction to Drug Disposition and Pharmacokinetics 2017 John Wiley & Sons, Ltd.
Contents
Introduction to pharmacokinetics: absorption, distribution and elimination (metabolism and excretion), disposition. Clinical pharmacokinetics, pharmacodynamics, kinetic homogeneity, models. Exponents and logarithms. Meaning of differential calculus, differential equations, integral calculus. AUC determination by trapezoidal rule. Orders of kinetic: first- and zero-order kinetics, Michaelis-Menten kinetic. Pharmacokinetics models: one-compartment and multiple compartments models. Non-compartment model. Concentration-time curves, rectilinear plots, semi-log plots. i.v. (bolus) single dose administration. Pharmacokinetic parameters associated with models and their calculation: C0, volume of distribution, clearance, elimination rate constant, half-life. Factors affecting drug distribution: characteristics of drug, characteristics of barrier to be crossed, regional blood flow, drug plasma and tissue protein binding, physiological factors and disease states. Blood-brain barrier and placenta transfer of drugs. Clearance: total plasma or blood clearance, organ clearance, extraction ratio. Well-stirred model of hepatic clearance, low and high hepatic extraction ratio drugs, renal clearance. Bioavailability. Route and frequency of administration: i.v. continuous constant rate infusion with and without reaching steady state; extra vascular administration and related parameters, single and multiple doses. Generic drugs, biotechnological and biosimilar drugs. Therapeutic drug monitoring, definition. Therapeutic ranges and reference ranges. TDM procedure, assay methods. Examples of drugs monitored. Theoretical background needed to make clinically useful TDM. Individual therapeutic concentration. Examples of drugs with non-linear kinetics.
Course Language
English
More information
The lecturer will provide .pdf presentations and other study materials of the topics discussed. He also receives by appointment in the presence or via the internet (Zoom platform) and can be contacted by email at fausto.feletti@unipv.it.
Degrees
Degrees
MEDICINE AND SURGERY (IN ENGLISH LANGUAGE)
Single-cycle Master’s Degree (6 Years)
6 years
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People
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