ID:
501698
Duration (hours):
52
CFU:
6
SSD:
PATOLOGIA GENERALE
Year:
2025
Overview
Date/time interval
Primo Semestre (29/09/2025 - 16/01/2026)
Syllabus
Course Objectives
The main goal of the General Pathology Course is to provide the student with the conceptual and scientific tools for studying and understanding the causes and mechanisms underlying diseases.
The specific objectives are:
1. Describe the main chemical, physical and biological pathogens and their effects (biological damage) on living matter, cells and tissues.
2. Analyze causal agents (etiology) and molecular mechanisms (pathogenesis) of diseases. To illustrate tissue reactions to biological damage that are determinant in pathological processes, with particular reference to the mechanisms of inflammation, healing of wounds, chronicization of pathological processes, and tumors.
3. Acquire the knowledge of scientific language and terms used in biological research for the purpose of obtaining a basic preparation needed for scientific research.
The specific objectives are:
1. Describe the main chemical, physical and biological pathogens and their effects (biological damage) on living matter, cells and tissues.
2. Analyze causal agents (etiology) and molecular mechanisms (pathogenesis) of diseases. To illustrate tissue reactions to biological damage that are determinant in pathological processes, with particular reference to the mechanisms of inflammation, healing of wounds, chronicization of pathological processes, and tumors.
3. Acquire the knowledge of scientific language and terms used in biological research for the purpose of obtaining a basic preparation needed for scientific research.
Course Prerequisites
General aspects of radiation physics. General Classification of Organic and Inorganic Chemicals. Cell morphology, energy metabolism and cell redox status. Structure and function of the extracellular matrix. Functions of inflammatory and immune cells. Lymphatic-endothelial system functions. Structure of microcirculation and organization of interstitial circulation. Characteristics of the cell cycle and differentiation process. DNA structure and function. Definition of mutation. Arterial wall structure. Lipoproteins metabolism. Functions of platelets, macrophages, smooth muscle cells and lymphocytes.
Teaching Methods
The course is divided into frontal lessons, classroom microscopic demonstrations and practical histopathology exercises.
The course is in fact associated with a laboratory in which the teacher and tutors will demonstrate the morpho-pathological characteristics of tissues and cells typical of the studied pathologies, through projection of images and histopathological preparations that will then be subjected of individual exercises at the microscope.
.
The course is in fact associated with a laboratory in which the teacher and tutors will demonstrate the morpho-pathological characteristics of tissues and cells typical of the studied pathologies, through projection of images and histopathological preparations that will then be subjected of individual exercises at the microscope.
.
Assessment Methods
Assessment of student knowledge learning is conducted through two tests:
- a written test consisting of extensive questions aimed to verify the understanding of concepts, and of multiple-choise questions aimed to verify the knowledge of the subject
- a microscope test to verify the recognition of histopathological preparations.
- a written test consisting of extensive questions aimed to verify the understanding of concepts, and of multiple-choise questions aimed to verify the knowledge of the subject
- a microscope test to verify the recognition of histopathological preparations.
Texts
Patologia generale (tomo I) – L. Altucci - G. Berton – B. Moncharmont – L.A. Stivala (Idealson - Gnocchi)
Patologia generale – M. Parola (Edises)
Patologia generale e fisiopatologia generale (tomo I) – G. M. Pontieri – M. A. Russo – L. Frati (Piccin)
Le basi della Patologia generale – S.R. Lakhani, S.A. Dilly, C.J. Finlayson, M.Gandhi (Cea- Casa editrice ambrosiana)
Le Basi patologiche delle malattie (Vol. I) – Robbins e Cotran (Elsevier-Masson)
Guida allo studio della Patologia generale – V. Vannini e L.A. Stivala
(PrintService)
The slides of the lectures will be available in Kiro site.
Patologia generale – M. Parola (Edises)
Patologia generale e fisiopatologia generale (tomo I) – G. M. Pontieri – M. A. Russo – L. Frati (Piccin)
Le basi della Patologia generale – S.R. Lakhani, S.A. Dilly, C.J. Finlayson, M.Gandhi (Cea- Casa editrice ambrosiana)
Le Basi patologiche delle malattie (Vol. I) – Robbins e Cotran (Elsevier-Masson)
Guida allo studio della Patologia generale – V. Vannini e L.A. Stivala
(PrintService)
The slides of the lectures will be available in Kiro site.
Contents
Etiology
Pathogens:
(A) intrinsic to the organism:
- genetic pathology
(B) extrinsic to the organism:
- environmental pathology due to chemical agents (e. g. damage mechanism, absorption and elimination pathways, organism defense mechanisms, exogenous and endogenous poisons)
- environmental pathology due to physical agents (e. g. radiations, high and low temperatures, atmospheric pressure variations);
- nutritional diseases
Cellular lesion
Adaptive responses: hyperplasia, hypertrophy, atrophy, metaplasia
Degenerations
Necrosis
Apoptosis
Inflammation
Causes, Acute Inflammation, Chronic Inflammation, Chemical Mediators, Systemic Aspects, Experimental Models
Healing processes
Regeneration, repair, resolution mechanisms
Tumors
Benign and malignant tumors, molecular bases of neoplastic transformation, invasion, metastasis,
causes, epidemiology, cancerogenesis and mutagenesis.
Relationships between inflammation, immunity and tumors
Complex lesions:
thrombus
atherosclerosis
Pathogens:
(A) intrinsic to the organism:
- genetic pathology
(B) extrinsic to the organism:
- environmental pathology due to chemical agents (e. g. damage mechanism, absorption and elimination pathways, organism defense mechanisms, exogenous and endogenous poisons)
- environmental pathology due to physical agents (e. g. radiations, high and low temperatures, atmospheric pressure variations);
- nutritional diseases
Cellular lesion
Adaptive responses: hyperplasia, hypertrophy, atrophy, metaplasia
Degenerations
Necrosis
Apoptosis
Inflammation
Causes, Acute Inflammation, Chronic Inflammation, Chemical Mediators, Systemic Aspects, Experimental Models
Healing processes
Regeneration, repair, resolution mechanisms
Tumors
Benign and malignant tumors, molecular bases of neoplastic transformation, invasion, metastasis,
causes, epidemiology, cancerogenesis and mutagenesis.
Relationships between inflammation, immunity and tumors
Complex lesions:
thrombus
atherosclerosis
Course Language
Italian
More information
The teacher is available by appointment for both explanations and viewing of written exams.
For the students belonging to the categories reported by the University, inclusive teaching will be planned from time to time
For the students belonging to the categories reported by the University, inclusive teaching will be planned from time to time
Degrees
Degrees
BIOLOGICAL SCIENCES
Bachelor’s Degree
3 years
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