The course aims to provide students with the theoretical and practical elements for the use of NMR spectroscopy in the determination of structures of organic molecules . During the course will be studied in detail both the proton and carbon-13 spectroscopy and the most important one- and two dimensional NMR experiments
Course Prerequisites
Inorganic Chemistry and Organic Chemistry foundational knowledge.
Teaching Methods
Lectures and active participation of students in classroom exercises on the interpretation of NMR spectra.
Assessment Methods
The final exam consists of an oral test in which the student will be asked to identify a possible structure of an organic compound based on the NMR spectra provided (1H, 13C. 13C-DEPT and COSY) and to explain in detail how the proposed structure agrees with the NMR data
Texts
D. H. Williams, I. Fleming, Spectroscopic Methods in Organic Chemistry, 6th ed., Tata Mcgraw Hill Education, 2011 M. Hesse, H. Meier, B. Zeeh, Spectroscopic Methods in Organic Chemistry, 2nd Edition, Georg Thieme Verlag, 2007. R.M. Silverstein, F. X. Webster, D. Kiemle, D. L. Bryce, Spectrometric Identification of Organic Compounds, 8th Edition, Wiley, 2014. H. Friebolin, Basic One- and Two- Dimensional NMR Spettroscopy, 3rd revised edition, Wiley-VCH,1998
Contents
1. Basic principles of NMR Spectroscopy 2. Proton and carbon-13 chemical shifts of organic compounds . Spectrum Analysis: spin systems. Relationship between the molecular structure and the spectrum : homotopic, enatiotopic and diastereotopic gropus. Chemical and magnetic equivalence 3. Indirect Spin - Spin Coupling, H,H and C-H coupling constants and chemical structure 4. Double resonance experiments. 5. Shift reagents and Dynamic NMR spectroscopy 6. Relaxation times T1 and T2 8. Nuclear Overhauser Effect 9. One-Dimensional and two dimensional experiments using complex pulse sequences
Course Language
Italian
More information
Since the course is chosen by the student, it is not possible to predict the extent of attendance, however as in previous years, the teacher guarantees the transmission of all the projected material and lecture notes.
