To provide deep knowledge of manufacturing technologies, preclinical characterization (in vitro and in vivo), industrialization and regulatory assessment.
Course Prerequisites
Knowledge of physiology, anatomy, histology, biopharmaceutics and pharmaceutical technology to understand medical devices for tissue engineering formulation and the cells homing and proliferation.
Teaching Methods
Lectures; visits to cell culture and manufacturing labs; team work on current literature; practical exercises on project development in the TE field. For students with specific needs, who cannot attend the teaching activities in person and who have applied for Inclusive Teaching Modes (Modalità Didattiche Inclusive), appropriate teaching material will be available for a profitable independent study. If required, self-learning can be supported by tutoring or integrative teaching activities, or dedicated meetings, including online, with flexibility of time according to needs.
Assessment Methods
Oral examination.
Texts
Notes provided.
Contents
The following topics will be developed: - technologies to manufacture medical devices for tissue engineering: 1) spinning technologies, 2) 3D printing, 4) microfluidics, 5) spray drying and 5) freeze-drying. - polymers/biopolymers to be used for devices manufacturing to increase the cell homing and proliferations. - preclinical characterization (in vitro and in vivo) to evaluate safety and effectiveness of the devices and the combination products. - industrialization and regulatory assessment.
