The purpose of the course is to guide the students through the main factors regulating the passage of molecules within the body and their effect via interaction/modulation of molecular endogenous cascades.
Course Prerequisites
The themes that will be examined during the course require a basic knowledge on the cell and its function, on the anatomy and organization of tissues/organs relevant for the drug route in the body.
Teaching Methods
Taught classes by PowerPoint presentations, sometimes associated with videos. The teacher tries to stimulate the students by asking some questions, also by using innovative tools (i.e, Wooclap). The educational material (slides) will be available on Kiro platform.
For the students with specific needs, who cannot attend in person the educational activities and applied for “Modalità Didattiche Inclusive” (Inclusive Teaching Methods), an adequate teaching material will be available for a fruitful self-study. If requested, the self-learning may be supported by tutoring activities or by supplementary activities, and by dedicated meetings, also online, with a flexible schedule according to the needs.
Assessment Methods
Conditions to pass the exam: passing the oral exam during one of the official exam sessions. For the students that attend the teaching classes (at least 75% of attendance), a pre-exam is also provided at the end of the course. The exam deals with questions on the topics regarding both Pharmacokinetics and Pharmacodynamics. The results will be published online, using the ESSE3 platform. Appropriate examination methods are planned for students who fall under the categories for Specific Learning Disorders (SLD) and Special Educational Needs (SEN).
Texts
- Ritter, Flower, Henderson, Loke, MacEwan, Robinson, Fullerton - Rang & Dale's Pharmacology – 10th Edition, ELSEVIER HEALTH SCIENCES, 2023. - Goodman & Gilman's. The Pharmacological Basis of Therapeutics - Brunton and Knollmann.14th edition, 2023.
OR Any textbook of Pharmacolgy
Contents
The course is aimed at providing knowledge on basic and advanced pharmacology. Specifically, the pharmacokinetics will be addressed to: general principles (ADME - absorption, distribution, metabolism and elimination, plasma concentration/time curves); main pharmacokinetic parameters and development of the mathematical model (calculation of the pharmacokinetic parameters - Cp, Vd, AUC, Kel, half-life, CL); hepatic and renal metabolism and elimination. Pharmacodynamics will be focused on: mechanism of action (proteins as binding targets); concept of potency, efficacy, and affinity; concept of agonist, antagonist, and partial agonist; different types of receptors and related signal transduction mechanisms; examples of molecular cascades; selective targeting of nanoparticles in order to increase the efficacy and safety; various types of nano-formulations for drug delivery and relative in vitro characterization and analysis.