The course aims to introduce the students to the world of computational protein design, i.e., teaching the current computational strategies to create <> proteins with new functions and possibly with therapeutic value. By the end of the course the students will be able to design small proteins independently.
Teaching Methods
The teaching methods are frontal teaching and pratical excerises on the computer.
Assessment Methods
Oral exam
Texts
Computational Protein Design: ISBN: 978-1-4939-6637-0
- An overview of the world of proteins. - Principles of "protein folding": what we already know about it. - Traditional approaches to "Protein Engineering" - Introduction to "Protein Design" and to computational methods. - Traditional approaches to "Protein Design". - "Machine-Learning" and "Protein Design". - Case studies: how to generate binding proteins without the need of a pre-existing scaffold. - Potential biotechnological use of <> created proteins.
