The course provides the knowledge to understand basic organic chemistry and the main organic reactions, organized by classes of compounds, through the recognition of functional groups. The goal is to predict the rectivity of simple organic molecules, through logical steps, describing the transformations of functional groups through the formalism of the curved arrows and formal charges (Reaction Mechanisms). Polyfunctional molecules, such as mono-, oligo-saccharides, glycosides, amino acids and oligopeptides are considered as well. The course also provides the basic elements to predict the three-dimensional shape of organic molecules (Organic Stereochemistry).
Course Prerequisites
Fundamentals of General and Inorganic Chemistry: Ionic and covalent bonds; Lewis structures, distance, energy and polarity of the bonds. Resonance concept. Formal charge and oxidation number. Acids and bases: Brønsted-Lowry and Lewis Theories. Fundamentals of thermodynamics and kinetics. Redox reactions.
Teaching Methods
Lecturing activities and problem-solving small groups and tutorials. Flipped Classrooms. For students with specific needs who are unable to attend in-person teaching activities and have applied for Inclusive Teaching Methods, suitable materials for independent study will be provided. These materials may include video recordings. If requested, self-learning support will be available through supplementary tutoring activities and dedicated meetings, which can be held online and scheduled flexibly based on individual needs.
Assessment Methods
The written exam is made by 15 questions (2 points for 13 questions + 3 points for 2 more challanging tests) on the theoretical aspects of the course, with particular emphasis on the reactivity of the functional groups embedded in organic molecules involved in bio-transformations.
Texts
1. Brown, Chimica Organica, 6° Ed. EdiSES. 2020 ISBN: 978-8833190556 2. Loudon, Organic Chemistry, 7th Ed. ISBN: 978-1319188429 3. Jonathan Clayden, Nick Greeves, Stuart Warren 2nd ed., Oxford University Press ISBN: 978-0199270293 Oxford University Press ISBN: 0199270295
Contents
1) Chemical bonding. 2) Covalent bonding in organic chemistry. 3) Organic acids and bases. 4) Structures and properties of alkanes and cycloalkanes 4a) Functional Groups. 5) Organic Stereochemistry, 6) Reaction mechanisms and intermediates. 7) Reactivity of alkenes and alkynes. 8) Alkyl halides. 9) Organometallics, organolithium, Grignard, Gilman, Organo-Zn 10) Alcohols, properties and Reactivity. 11) Ethers, thiols and oxiranes. 12) Amines. 13) Ketones and aldehydes. 14) Carboxylic acids and derivatives 15) Lipids. 16) Aromatic compounds. Phenols and Hydroquinones. 17) Monosaccharides, Glycosides, oligosaccharides.