ID:
509695
Duration (hours):
48
CFU:
6
SSD:
CHIMICA FISICA
Year:
2025
Overview
Date/time interval
Secondo Semestre (02/03/2026 - 12/06/2026)
Syllabus
Course Objectives
The main objective of the course is to provide the student with the elements necessary to deal with the problems relating to solids of pharmaceutical interest with a chemical-physical method.
The student will acquire a particular awareness of the critical points of the pharmaceutical preformulation phase. He will also acquire skills in the physico-chemical techniques for investigating the solid state of drugs - instrumentation, measurement principles, applications - in order to be able to process and interpret experimental data and autonomously design experiments.
At the end of the course the student will get the methodological bases and the knowledge necessary to face the physico-chemical studies in drug research and development laboratories.
The student will acquire a particular awareness of the critical points of the pharmaceutical preformulation phase. He will also acquire skills in the physico-chemical techniques for investigating the solid state of drugs - instrumentation, measurement principles, applications - in order to be able to process and interpret experimental data and autonomously design experiments.
At the end of the course the student will get the methodological bases and the knowledge necessary to face the physico-chemical studies in drug research and development laboratories.
Course Prerequisites
In order better enjoy the contents of this course, students should have an adequate starting preparation in the knowledge of general chemistry (systems composition, nature of chemical bonds, principles of the chemical equilibrium), physical chemistry (thermodynamic functions, phase diagrams, chemical kinetics) and of the chemistry of organic compounds (recognition of functional groups).
Teaching Methods
The course is organized in: -Frontal lessons held with the aid of PowerPoint presentations projected on the screen. -Workshop lessons in which the instruments and the analysis procedures are presented, and which allow a practical approach by the student to the techniques.
The active participation of the student is strongly encouraged.
For students with specific needs, who cannot attend teaching activities in person and who have applied for Inclusive Teaching Modality, adequate teaching material will be available for fruitful independent study. If requested, self-learning can be supported by tutoring or supplementary teaching activities, and by dedicated meetings, including online, with time flexibility depending on needs
The active participation of the student is strongly encouraged.
For students with specific needs, who cannot attend teaching activities in person and who have applied for Inclusive Teaching Modality, adequate teaching material will be available for fruitful independent study. If requested, self-learning can be supported by tutoring or supplementary teaching activities, and by dedicated meetings, including online, with time flexibility depending on needs
Assessment Methods
The final test relating to the topics of Module 1 and 2 provides for the student's personal deepening of topics chosen at will or the study of scientific articles relating to the topics covered and subsequent presentation/discussion with the aim of assessing the quality of learning as well as the ability of elaboration of the concepts learned in the course. The use of an appropriate scientific language will also be assessed.
The partial assessments of to the two modules contribute to forming the overall assessment of the teaching. The exam will therefore consist of a PowerPoint presentation followed by in-depth questions covering all the topics of the course. For the second module, there will also be an exercise involving the identification of one or more polymorphs using databases.
The partial assessments of to the two modules contribute to forming the overall assessment of the teaching. The exam will therefore consist of a PowerPoint presentation followed by in-depth questions covering all the topics of the course. For the second module, there will also be an exercise involving the identification of one or more polymorphs using databases.
Texts
P. Atkins, J. de Paula, J. Keeler, “Chimica Fisica”, Zanichelli.
A. Martin, “Physical Pharmacy”, Lea & Febiger
A. Martin, “Physical Pharmacy”, Lea & Febiger
Contents
Module 1 (G. Bruni): The research and development steps of a new active ingredient (preclinical studies, clinical studies, registration phase). The amorphous phase and the crystalline solid state. Polymorphs and solvates / hydrates. Thermodynamic aspects of polymorphism. Properties of polymorphs. Polymorphic transitions and relationships. Polymorph screening. Polymorphism and patent aspects.
Thermal techniques (DSC and TGA): operating principles, instrumentation, interpretation and data processing. Applications of the thermal techniques to the study of polymorphism, to the quantification of different solid phases in the pharmaceutical products, to drug-excipient compatibility studies, to the characterization of binary systems for the improvement of solubility and dissolution rate of active ingredients.
Module 2 (L. Malavasi): Use of diffraction technique to investigate the solid state of active pharmaceutical ingredients. Hints on the application of advanced synchrotron-based diffraction technique to investigate amorphous and low-crystalline materials. Implication for intellectual property issue of diffraction. Application of FT-IR and Raman spectroscopies to investigate polymorphisms, co-crystals, solvates and hydrates.
Thermal techniques (DSC and TGA): operating principles, instrumentation, interpretation and data processing. Applications of the thermal techniques to the study of polymorphism, to the quantification of different solid phases in the pharmaceutical products, to drug-excipient compatibility studies, to the characterization of binary systems for the improvement of solubility and dissolution rate of active ingredients.
Module 2 (L. Malavasi): Use of diffraction technique to investigate the solid state of active pharmaceutical ingredients. Hints on the application of advanced synchrotron-based diffraction technique to investigate amorphous and low-crystalline materials. Implication for intellectual property issue of diffraction. Application of FT-IR and Raman spectroscopies to investigate polymorphisms, co-crystals, solvates and hydrates.
Course Language
Italian
More information
The teachers are available to meet the student for clarifications by making an appointment via email.
Teachers' email address:
giovanna.bruni@unipv.it
lorenzo.malavasi@unipv.it
Teachers' email address:
giovanna.bruni@unipv.it
lorenzo.malavasi@unipv.it
Degrees
Degrees
CHEMISTRY
Master’s Degree
2 years
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