This course investigates the fundamental concepts and methods for the study of the structures of biological macromolecules with a focus on the implications for drug development and design.
Course Prerequisites
This course is suggested for students who have acquired excellent knowledge in molecular biology, chemistry, and mathematics during their bachelor studies.
Teaching Methods
Lectures. For students who certify that they are in one of the categories indicated by the University (disabled, workers, etc.) the teachers will be able to provide support based on what is indicated by the University, or through meetings for clarifications on certain topics of the course and possibly providing the corresponding videotapes of lessons from past years that include those specific topics.
Assessment Methods
The exam consists of an oral exam in which the student will be asked to reply on questions related to both course parts and, if sufficient, the final mark (agreed by both teachers) will be on a scale range of 18 to 30 cum laude.
Texts
Physical Biochemistry: Principles and Applications, 2nd Edition David Sheehan Wiley-Blackwell
Structural Biology Using Electrons and X-rays An Introduction for Biologist Michael F. Moody Academic press https://doi.org/10.1016/C2009-0-01500-1
Contents
Methods for the study of the three-dimensional structure of biological macromolecules. Introduction to biocrystallography. Diffraction theory. The phase problem and methods for its solution. Experimental methods in biocrystallography. NMR spectroscopy Single particle EM 3D image reconstruction Structure-based drug design Examples of the application of the structural biology methods for drug development. Artificial intelligence and structure prediction.
Course Language
English
More information
Attending the lectures will be critical for swiftly learning the topics covered by the course.
