Synthesis of Nornicotine, Nicotine and Other Functionalised Derivatives Using Solid-Supported Reagents and Scavengers

The sequential use of solid-supported reagents and scavengers has led to an efficient synthesis of the natural products nornicotine 1, nicotine 2 and further fuctionalised derivatives. Also reported is a diastereoselective route to both enantiomers of nicotine 2.