Aberrant somatic hypermutation in transformation of follicular lymphoma and chronic lymphocytic leukemia to diffuse large B-cell lymphoma
Academic Article
Publication Date:
2006
abstract:
The molecular mechanisms involved in histologic transformation of follicular lymphoma (FL) and B-chronic lymphocytic leukemia (B-CLL) to diffuse large B-cell lymphoma (DLBCL) are heterogeneous and largely unknown. Here we explored whether aberrant somatic hypermutation, leading to the acquisition of new mutations in PIM-1, PAX-5, RhoH/TTF and c-MYC genes, is involved in transformation from FL or B-CLL to DLBCL. Eighteen sequential pairs of FL/DLBCL (n=9) and B-CLL/DLBCL (n=9) were investigated. Our findings demonstrate that acquisition of novel mutations due to aberrant somatic hypermutation was associated with DLBCL transformation in 5/9 (55.5%) cases of FL and 2/9 (22.2%) cases of B-CLL.
Iris type:
1.1 Articolo in rivista
Keywords:
LYMPHOMA; FOLLICULAR LYMPHOMA; CHRONIC LYMPHOCITIC LEUKEMIA
List of contributors:
Rossi, D; Berra, E; Cerri, M; Deambrogi, C; Barbieri, C; Franceschetti, S; Lunghi, M; Conconi, A; Paulli, Marco; Matolcsy, A; Pasqualucci, L; Capello, D; Gaidano, G.
Published in: