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Sex differences in oncogenic mutational processes

Academic Article
Publication Date:
2020
abstract:
Sex differences have been observed in multiple facets of cancer epidemiology, treatment and biology, and in most cancers outside the sex organs. Efforts to link these clinical differences to specific molecular features have focused on somatic mutations within the coding regions of the genome. Here we report a pan-cancer analysis of sex differences in whole genomes of 1983 tumours of 28 subtypes as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium. We both confirm the results of exome studies, and also uncover previously undescribed sex differences. These include sex-biases in coding and non-coding cancer drivers, mutation prevalence and strikingly, in mutational signatures related to underlying mutational processes. These results underline the pervasiveness of molecular sex differences and strengthen the call for increased consideration of sex in molecular cancer research.
Iris type:
1.1 Articolo in rivista
Keywords:
Chromosomal Instability; Exome; Female; Genome, Human; Genomic Instability; Humans; Logistic Models; Male; Neoplasms; Oncogenes; Open Reading Frames; beta Catenin; Mutation; Sex Characteristics
List of contributors:
Li, C. H.; Prokopec, S. D.; Sun, R. X.; Yousif, F.; Schmitz, N.; Al-Shahrour, F.; Atwal, G.; Bailey, P. J.; Biankin, A. V.; Boutros, P. C.; Campbell, P. J.; Chang, D. K.; Cooke, S. L.; Deshpande, V.; Faltas, B. M.; Faquin, W. C.; Garraway, L.; Getz, G.; Grimmond, S. M.; Haider, S.; Hoadley, K. A.; Jiao, W.; Kaiser, V. B.; Karlic, R.; Kato, M.; Kubler, K.; Lazar, A. J.; Li, C. H.; Louis, D. N.; Margolin, A.; Martin, S.; Nahal-Bose, H. K.; Nielsen, G. P.; Nik-Zainal, S.; Omberg, L.; P'Ng, C.; Perry, M. D.; Polak, P.; Rheinbay, E.; Rubin, M. A.; Semple, C. A.; Sgroi, D. C.; Shibata, T.; Siebert, R.; Smith, J.; Stein, L. D.; Stobbe, M. D.; Sun, R. X.; Thai, K.; Wright, D. W.; Wu, C. -L.; Yuan, K.; Zhang, J.; Boutros, P. C.; Aaltonen, L. A.; Abascal, F.; Abeshouse, A.; Aburatani, H.; Adams, D. J.; Agrawal, N.; Ahn, K. S.; Ahn, S. -M.; Aikata, H.; Akbani, R.; Akdemir, K. C.; Al-Ahmadie, H.; Al-Sedairy, S. T.; Al-Shahrour, F.; Alawi, M.; Albert, M.; Aldape, K.; Alexandrov, L. B.; Ally, A.; Alsop, K.; Alvarez, E. G.; Amary, F.; Amin, S. B.; Aminou, B.; Ammerpohl, O.; Anderson, M. J.; Ang, Y.; Antonello, D.; Anur, P.; Aparicio, S.; Appelbaum, E. L.; Arai, Y.; Aretz, A.; Arihiro, K.; Ariizumi, S. -I.; Armenia, J.; Arnould, L.; Asa, S.; Assenov, Y.; Atwal, G.; Aukema, S.; Auman, J. T.; Aure, M. R.; Awadalla, P.; Aymerich, M.; Bader, G. D.; Baez-Ortega, A.; Bailey, M. H.; Bailey, P. J.; Balasundaram, M.; Balu, S.; Bandopadhayay, P.; Banks, R. E.; Barbi, S.; Barbour, A. P.; Barenboim, J.; Barnholtz-Sloan, J.; Barr, H.; Barrera, E.; Bartlett, J.; Bartolome, J.; Bassi, C.; Bathe, O. F.; Baumhoer, D.; Bavi, P.; Baylin, S. B.; Bazant, W.; Beardsmore, D.; Beck, T. A.; Behjati, S.; Behren, A.; Niu, B.; Bell, C.; Beltran, S.; Benz, C.; Berchuck, A.; Bergmann, A. K.; Bergstrom, E. N.; Berman, B. P.; Berney, D. M.; Bernhart, S. H.; Beroukhim, R.; Berrios, M.; Bersani, S.; Bertl, J.; Betancourt, M.; Bhandari, V.; Bhosle, S. G.; Biankin, A. V.; Bieg, M.; Bigner, D.; Binder, H.; Birney, E.; Birrer, M.; Biswas, N. K.; Bjerkehagen, B.; Bodenheimer, T.; Boice, L.; Bonizzato, G.; De Bono, J. S.; Boot, A.; Bootwalla, M. S.; Borg, A.; Borkhardt, A.; Boroevich, K. A.; Borozan, I.; Borst, C.; Bosenberg, M.; Bosio, M.; Boultwood, J.; Bourque, G.; Boutros, P. C.; Bova, G. S.; Bowen, D. T.; Bowlby, R.; Bowtell, D. D. L.; Boyault, S.; Boyce, R.; Boyd, J.; Brazma, A.; Brennan, P.; Brewer, D. S.; Brinkman, A. B.; Bristow, R. G.; Broaddus, R. R.; Brock, J. E.; Brock, M.; Broeks, A.; Brooks, A. N.; Brooks, D.; Brors, B.; Brunak, S.; Bruxner, T. J. C.; Bruzos, A. L.; Buchanan, A.; Buchhalter, I.; Buchholz, C.; Bullman, S.; Burke, H.; Burkhardt, B.; Burns, K. H.; Busanovich, J.; Bustamante, C. D.; Butler, A. P.; Butte, A. J.; Byrne, N. J.; Borresen-Dale, A. -L.; Caesar-Johnson, S. J.; Cafferkey, A.; Cahill, D.; Calabrese, C.; Caldas, C.; Calvo, F.; Camacho, N.; Campbell, P. J.; Campo, E.; Cantu, C.; Cao, S.; Carey, T. E.; Carlevaro-Fita, J.; Carlsen, R.; Cataldo, I.; Cazzola, M.; Cebon, J.; Cerfolio, R.; Chadwick, D. E.; Chakravarty, D.; Chalmers, D.; Chan, C. W. Y.; Chan, K.; Chan-Seng-Yue, M.; Chandan, V. S.; Chang, D. K.; Chanock, S. J.; Chantrill, L. A.; Chateigner, A.; Chatterjee, N.; Chayama, K.; Chen, H. -W.; Chen, J.; Chen, K.; Chen, Y.; Chen, Z.; Cherniack, A. D.; Chien, J.; Chiew, Y. -E.; Chin, S. -F.; Cho, J.; Cho, S.; Choi, J. K.; Choi, W.; Chomienne, C.; Chong, Z.; Choo, S. P.; Chou, A.; Christ, A. N.; Christie, E. L.; Chuah, E.; Cibulskis, C.; Cibulskis, K.; Cingarlini, S.; Clapham, P.; Claviez, A.; Cleary, S.; Cloonan, N.; Cmero, M.; Collins, C. C.; Connor, A. A.; Cooke, S. L.; Cooper, C. S.; Cope, L.; Corbo, V.; Cordes, M. G.; Cordner, S. M.; Cortes-Ciriano, I.; Covington, K.; Cowin, P. A.; Craft, B.; Craft, D.; Creighton, C. J.; Cun, Y.; Curley, E.; Cutcutache, I.; Czajka, K.; Czerniak, B.; Dagg, R. A.; Danilova, L.; Davi, M. V.; Davidson, N. R.; Davies, H.; Davis, I. J.; Davis-Dusenbery, B. N.; Dawson, K. J.; De La Vega, F. M.; De Paoli-Iseppi, R.; De
Authors of the University:
MALCOVATI LUCA
Handle:
https://iris.unipv.it/handle/11571/1369454
Published in:
NATURE COMMUNICATIONS
Journal
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URL

https://www.nature.com/articles/s41467-020-17359-2
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