JAK2 (V617F) mutation in healthy individuals

Here, we report a study of JAK2 (V617F) mutation in 75 normal subjects referred to the Outpatient Section of the Department of Haematology of Pavia. These healthy individuals (aged from 18 to 79 years) displayed a normal blood cell count without spleen enlargement. Applying AS-PCR as previously described (Passamonti et al, 2006), we did not find the mutation in any case.